Biomimetic Approaches for Biomaterials Development

PREFACE
 
PART I: Examples of Natural and Nature-Inspired Materials
 
BIOMATERIALS FROM MARINE-ORIGIN BIOPOLYMERS
Taking Inspiration from the Sea
Marine-Origin Biopolymers
Marine-Based Tissue Engineering Approaches
Conclusions
 
HYDROGELS FROM PROTEIN ENGINEERING
Introduction
Principles of Protein Engineering
Structural Diversity and Applications of Protein-Engineered Hydrogels
Development of Biomimetic Protein-Engineered Hydrogels for Tissue Engineering Applications
Conclusions and Future Perspective
 
COLLAGEN-BASED BIOMATERIALS FOR REGENERATIVE MEDICINE
Introduction
Collagens In Vivo
Collagen In Vitro
Collagen Hydrogels
Collagen Sponges
Multichannel Collagen Scaffolds
What Tissues Do Collagen Biomaterials Mimic? (see Table 3.1)
Concluding Remarks
 
SILK-BASED BIOMATERIALS
Introduction
Silk Proteins
Mechanical Properties
Biomedical Applications of Silk
Final Remarks
 
ELASTINLIKE MACROMOLECULES
General Introduction
Materials Engineering - an Overview on Synthetic and Natural Biomaterials
Elastin as a Source of Inspiration for Nature-Inspired Polymers
Nature-Inspired Biosynthetic Elastins
ELRs as Advanced Materials for Biomedical Applications
Conclusions
 
BIOMIMETIC MOLECULAR RECOGNITION ELEMENTS FOR CHEMICAL SENSING
Introduction
Theory of Molecular Recognition
Molecularly Imprinted Polymers
Supramolecular Chemistry
5 Biomolecular Materials
Summary and Future of Biomimetic-Sensor-Coating Materials
 
PART II: Surfaces Aspects
 
BIOLOGY LESSONS FOR ENGINEERING SURFACES FOR CONTROLLING CELL- MATERIAL ADHESION
Introduction
The Extracellular Matrix
Protein Structure
Basics of Protein Adsorption
Kinetics of Protein Adsorption
Cell Communication
Cell Adhesion Background
Integrins and Adhesive Force Generation Overview
Adhesive Interactions in Cell, and Host Responses to Biomaterials
Model Systems for Controlling Integrin-Mediated Cell Adhesion
Self-Assembling

Joao F. Mano is Assistant Professor at the University of Minho, Portugal, and staff member of the 3B's research group Biomaterials, Biodegradables and Biomimetics. He obtained his PhD in Chemistry in 1996 from the Technical University of Lisbon. His current research interests include the development of new materials and concepts for biomedical applications, especially aimed at being used in tissue engineering of bone and cartilage and in the controlled delivery of bioactive molecules. Joao F. Mano is author or co-author of about 270 scientific works, eleven book chapters and one patent. He was awarded the Stimulus to Excellence by the Portuguese Minister for Science and Technology in 2005, which recognizes the most productive scientists working in Portugal, and the Materials Science and Technology Prize by the Federation of European Materials Societies in 2007.