Cancer Biology and Therapeutics

Section I Biochemistry of the Cancer Cell and Selectivity of Drug Action.- Biochemical Strategy of Cancer Cells and the Targeting of Chemotherapy with Tiazofurin, Acivicin, and Dipyridamole.- The Biological Bases for the Design of Anticancer Agents.- Biochemistry of Methotrexate: Teaching an Old Drug New Tricks.- Section II Biological and Clinical Implications of Tumor Cell Heterogeneity and Metastases.- Biological and Clinical Implications of the Stem Cell Concept in Human Malignancy.- Membrane Properties of Lewis Lung Tumor Cells with "Low" and "High" Metastatic Capacity: Anti-metastatic Effect of a Glycosaminoglycan Biosynthesis Blocking Agent 5-Hexyl-2?-deoxyuridine (HUdR).- Implications of Therapy-induced Genetic/Epigenetic Modulations of Tumor Progression and Tumor Cell Heterogeneity for the Treatment of Cancer.- Section III Approaches to the Treatment and Diagnosis of Cancer.- Site-directed Combination Chemotherapy.- Sugar Analogs and 5-Fluorouridine in Combination Chemotherapy.- New Strategies for the Improvement of Alkylating Antitumor Agents.- Application of Proton Nuclear Magnetic Resonance to Tumor Biology.- Section IV Clinical Advances and Problems in the Treatment of Human Tumors.- Relationships of Cell Biology to Therapy in Childhood Leukemia.- Clinical Cancer Treatment and Drug Resistance: The Interface of the Clinic and the Laboratory.- Section V Induction, Prevention, and Modulation of Cancer.- Nitrosamines and Human Cancer: Some Implications of Basic Research.- Molecular Mechanisms in Protection Against Carcinogenesis.- Antineoplastic Agents and Cancer Cell Differentiation.- Section VI Immunological Aspects of Neoplasia.- A Reappraisal of Cytotoxic Lymphocytes in Human Tumor Immunology.- From Tumor Relapse Prevention to Tumor Induction Prevention.- Participants.