Chemical Biology, 3 Vols.

INTRODUCTION

USING SMALL MOLECULES TO EXPLORE BIOLOGY

- Using natural products to unravel biological mechanisms

- Engineering control over protein function using chemistry

- Controlling protein-protein interactions

- Expanding the genetic code

DISCOVERING SMALL MOLECULE PROBES FOR BIOLOGICAL MECHANISMS

- Forward chemical genetics

- Reverse chemical genetics revisited

- Tags and probes for chemical biology

EXPANDING THE SCOPE OF CHEMICAL SYNTHESIS

- Diversity-oriented synthesis

- Synthesis of large biological molecules

- Advances in sugar chemistry

- Biosynthesis of natural products libraries

CHEMICAL INFORMATICS

- The Concept of Diversity Space

- In silico Screening

DRUG DISCOVERY

- Molecular Tools in Drug Discovery

- The Target Family Approach

- Prediction of ADMET properties

SYSTEMS BIOLOGY

- Computational methods and modeling

- Genome and proteome studies

OUTLOOK

Stuart L. Schreiber is the Chair of the Department of Chemistry and Chemical Biology at Harvard University (Boston). He is also a co-founder of the Broad Institute, a joint initiative of Harvard University and MIT. For his pioneering achievements in establishing chemical biology as a new field in chemistry, Professor Schreiber has received numerous awards, among them the ACS Awards in Synthetic Organic Chemistry (1994), and Bioorganic Chemistry (2000), and the Tetrahedron Prize for Creativity in Organic Chemistry (1997).Tarun Kapoor is the Head of the Laboratory of Chemistry and Cell Biology at Rockefeller University (New York). He joined the Rockefeller faculty in 2001 after a postdoctorate with Stuart Schreiber at Harvard University. Research in the Kapoor laboratory focuses on the discovery of small molecule probes for cell division using diversity-oriented synthesis.Günther Wess is the Head of the GSF Institute for Health and Environment in Neuherberg (Germany). Before being appointed to that position, he was the Head of Research and Development Europe of the Sanofi-Aventis corporation. Under his leadership at Aventis, the principles of Chemical Biology have become indispensable for answering basic questions in early drug discovery.

"...Overall, there is no doubt that these three volumes will be the fauthoritative reference for those already working in the field and researchers wanting to get acquainted with the various topics in chemical biology. The informationen is clearly given by leading figures in each subdiscipline of chemical biology, and the reader can go straight to the chapter of interest. The book could also serve as support for teaching."ChemBioChem, 07/2007"...I found the book very stimulating, also in fields where I do not feel at home. It can also be used as a refernce book for the aread of chemical biology that are covered. I recommend it for a readership taht extends from then advanced PhD student with an interest in the subject to scientists already working in the field."Angewandte Chemie International Edition, 10/2007