Chemistry for Pharmacy Students

Preface

1. Introduction

1.1 Role of chemistry in modern life

1.2 Physical properties of drug molecules

2. Atomic structure and bonding

2.1 Atoms, elements and compounds

2.2 Atomic structure: orbitals and electronic configurations

2.3 Chemical bonding theories: formation of chemical bonds

2.4 Electronegativity and chemical bonding

2.5 Bond polarity and intermolecular forces

2.6 Significance of chemical bonding in drug-receptor interactions

3. Stereochemistry

3.1 Stereochemistry: definition

3.2 Isomerism

3.3 Significance of stereoisomerism in determining drug action and toxicity

3.4 Synthesis of chiral molecules

3.5 Separation of stereoisomers: resolution of racemic mixtures

3.6 Compounds with stereocentres other than carbon

3.7 Chiral compounds that do not have a tetrahedral atom with four different groups

4. Organic functional groups

4.1 Organic functional groups: definition and structural features

4.2 Hydrocarbons

4.3 Alkanes, cycloalkanes and their derivatives

4.4 Alkenes and their derivatives

4.5 Alkynes and their derivatives

4.6 Aromatic compounds and their derivatives

4.7 Heterocyclic compounds and their derivatives

4.8 Nucleic acids

4.9 Amino acids and peptides

4.10 Importance of functional groups in determining drug actions and toxicity

4.11 Importance of functional groups in determining stability of drugs

5. Organic reactions

5.1 Types of organic reaction

5.2 Radical reactions: free radical chain reactions

5.3 Addition reactions

5.4 Elimination reactions: 1,2-elimination or ß-elimination

5.5 Substitution reactions

5.6 Hydrolysis

5.7 Oxidation?reduction reactions

5.8 Pericyclic reactions

6. Natural product chemistry

6.1 Introduction to natural products drug discovery process

6.2 Alkaloids

6.3 Carbohydrates

6.4 Glycosides

6.5 Terpenoids

6.6 Steroids

6.7 Phenolics

Dr. Satyajit Sarker. Reader in Pharmacy, School of Biomedical Sciences, University of Ulster in Coleraine, Cromore Road, Coleraine, BT52 1SA, UK. . E-mail: s.sarker@ulster.ac.uk.

Co-author: Dr. Lutfun Nahar. 5 The Walled Garden, Coleraine Co. Londonderry, BT51 3BF, UK. E-mail: lnahar2003@yahoo.co.uk.

"...tailor-made for Pharmacy and Pharmaceutical Sciences students... while also invaluable for students of various other subject areas..." (Coleraine Times, 29th August 2007)

"... Provides a comprehensive overview on topics within the areas of general, organic and natural products chemistry..." (Limavady Chronicle, Wednesday 12th September 2007)