CNS Cancer: Models, Markers, Prognostic Factors, Targets, and Therapeutic Approaches

Chapter 1: PDGF-Based Malignant Glioma Model in Rats and Mice.- Chapter 2: Modeling Brain Tumors Using Avian Retroviral Gene Transfer.- Chapter 3: Using Neurofibromatosis Type 1 Mouse Models to Understand Human Pediatric Low-Grade Gliomas.- Chapter 4: Transgenic Mouse Models of CNS Tumors: Using Genetically Engineered Murine Models to Study the Role p21-Ras in Glioblastoma Multiforme.- Chapter 5: Pten-Deficient Mouse Models for High-Grade Astrocytomas.- Chapter 6: The NF1/p53 Knockout Transgenic Model for Malignant Glioma.- Chapter 7: Conditional Models for Brain Tumors in Transgenic Mice.- Chapter 8: Human Brain Tumor Cell and Tumor Tissue Transplantation Models.- Chapter 9: Transformation of Human Brain Cells in Culture as Models for Brain Tumors.- Chapter 10: History of Important Carcinogen-Induced Brain Tumor Cell Lines.- Chapter 11: Neuro-Oncogenesis Induced by Nitroso-Compounds in Rodents and Strain-Specific Genetic Modifiers of Predisposition.- Chapter 12: The Murine GL261 Glioma Experimental Model to Assess Novel Brain Tumor Treatments.- Chapter 13: Spontaneous Occurrence of Brain Tumors in Animals: Opportunities as Preclinical Model Systems.- Chapter 14: P53 Alterations in Brain Tumors.- Chapter 15: The PTEN/PI3 Kinase Pathway in Human Glioma.- Chapter 16: Value of 1p/19q and Other LOH Markers for Brain Tumor Diagnosis, Prognosis and Therapy.- Chapter 17: Discovery of Genetic Markers for Brain Tumors by Comparative Genomic Hybridization.- Chapter 18: Genomic Identification of Significant Targets in Brain Cancer.- Chapter 19: Oncogenic Pathway Markers.- Chapter 20: Aberrant EGFR Signaling in Glioma.- Chapter 21: Mechanisms of Brain Tumor Angiogenesis.- Chapter 22: Vaso-Occlusive Mechanisms that Intiate Hypoxia and Necrosis in Glioblastoma: The Role of Thrombosis and Tissue Factor.- Chapter 23: Expression Profiling of Glioblastoma Defines Distinct Subtypes.- Chapter 24: Proteomic Profiling of Human Brain Tumors.- Chapter 25: Discovery of Biomarkers in the

Erwin G Van Meir is Professor of Neurosurgery and Hematology & Medical Oncology in the School of Medicine at Emory University. A native of Belgium, he obtained Bachelor's degrees in Biology and Education at the University of Fribourg, Switzerland. He pursued graduate studies in Molecular Virology at the University of Lausanne, Switzerland where he obtained his PhD in 1989. He then became interested in cancer and pursued postdoctoral work at the University Hospital in Lausanne and at the Ludwig Institute for Cancer Research in San Diego. In 1994 he became a Junior Faculty and Director of the Laboratory of Brain Tumor Biology and Genetics in the Neurosurgery Department at the University of Lausanne. In 1998 he joined Emory University in Atlanta, where he now serves as the Leader of the Winship Cancer Institute Molecular Pathways and Biomarkers scientific program and as the co-Director of the brain tumor working group.