Combinatorial Library

Part I. Library Synthesis and Quality Control Using a Noncovalent Protection Strategy to Enhance Solid-Phase Synthesis Fahad Al-Obeidi, John F. Okonya, Richard E. Austin, and Dan R. S. Bond Quality Control of Solid-Phase Synthesis by Mass Spectrometry Jean-Louis Aubagnac, Robert Combarieu, Christine Enjalbal, and Jean Martinez Preparation of Encoded Combinatorial Libraries for Drug Discovery Tao Guo and Doug W. Hobbs Simple Tools for Manual Parallel Solid Phase Synthesis Viktor Krchnák and Andrew Burritt Cleavage of Compounds from Solid Phase by Gaseous Reagents Viktor Krchnák Synthesis of DNA-Binding Polyamides: Robust Solid-Phase Methods for Coupling Heterocyclic Aromatic Amino Acids Peter O. Krutzik and A. Richard Chamberlin The Preparation of Phenyl-stilbene Derivatives Using the Safety Catch Linker Amy Lew and A. Richard Chamberlin Host-Guest Chemistry: Combinatorial Receptors Brian R. Linton Automated Structure Verification of Small Molecules Libraries Using 1D and 2D NMR Techniques Gérard Rossé, Peter Neidig, and Harald Schröder Rapid Liquid-Phase Combinatorial Synthesis of Heterocyclic Libraries Chung-Ming Sun Soluble Polymer-Supported Methods for Combinatorial and Organic Synthesis Paul Wentworth, Jr. and Carsten Spanka Analytical Methods for Optimization and Quality Control of Combinatorial Synthesis Bing Yan, Liling Fang, Mark M. Irving, Jiang Zhao, Diana Liu, Gianine M. Figliozzi, Frank Woolard, and Clinton A. Krueger Part II. Library Purification and Screening Resolving Racemic Mixtures Using Parallel Combinatorial Libraries Tingyu Li, Yan Wang, and Louis H. Bluhm Ligand Libraries for the Extraction of Metal Ions: Dynamic Combinatorial and High-Throughput Screening Methods Seema Choudhary and Janet R. Morrow Automated Liquid-Liquid Extraction and Ion-Exchange Solid-Phase Extraction for Initial Purification Sean X. Peng and Charles Henson On-Bead and Solution Screening Approaches for Genomically Derived Targets: Discovery of Surrogate Ligands and

"...an excellent work that covers many important aspects, gives easy access to literature for further study, and contains much practical advice. As it describes many different tools and techniques it is especially suitable for beginners in combinatorial chemistry, and deserves to be added to the list of well presented works in this field." -- Angewandte Chemie

"The book provides a wealth of excellent reference material and it is a worthwhile addition to the library of most medicinal chemists." -- Journal of Medicinal Chemistry

"...an excellent work that covers many important aspects, gives easy access to literature for further study, and contains much practical advice. As it describes many different tools and techniques it is especially suitable for beginners in combinatorial chemistry, and deserves to be added to the list of well presented works in this field." - Angewandte Chemie

"The book provides a wealth of excellent reference material and it is a worthwhile addition to the library of most medicinal chemists." -Journal of Medicinal Chemistry