Computational Toxicology

FOREWORD
1. INTRODUCTION
2. PBPK, QSAR and TOXICITY PATHWAYS: CHEMICAL SCREENING AND PRIORITZATION TOOLS
3. COMPUTATIONAL RISK ASSESSMENT OF UNTESTED HAZARDOUS CHEMICAL AGENTS RELEASTED IN THE WATER ENVIRONMENT
4. RISK ASSESSMENT OF CHEMICAL MIXTURES
5. MODELING SENSITIVE SUB-POPULATIONS FOR RISK ASSESSMENT
6. COMPUTATIONAL METHODS FOR TOXICOGENOMIC ANALYSES FOR RISK ASSESSMENT
7. INTEGRATED SYSTEMS BIOLOGY APPROACHES TO PREDICTING DRUG-INDUCED LIVER TOXICITY
8. COMPUTATIONAL TRANSLATION AND INTEGRATION OF TEST DATA TO MEET RISK ASSESSEMENT GOALS
9. COMPUTATIONAL TRANSLATION OF DATA FROM NON-MAMMALIAN SPECIES TO MEET REACH INFORMATIONAL STRATEGIES
10. DEVLOPMENT OF IN SILICO TISSUE MODELS FOR RISK ASSESSMENT
11. EXAMPLES OF SIMULATIONS WITH A NEWLY DEVELOPED GENERIC PBTK -MODEL FOR INCORPORATING HUMAN BIOMONITORING DATA TO MEET REACH GUIDELINES
12. USE OF PUBLIC DATA SETS for RISK ASSESSMENT
13. COMPUTATIONAL TOXICOLOGY AND APPLICATIONS FOR RISK ASSESSMENTS OF PHARMACEUTICALS
14. DECISION FOREST: A NOVEL PATTERN RECOGNITION METHOD FOR IN SILICO RISK ASSESSMENT
15. TRANSLATION OF COMPUTATIONAL MODEL RESULTS
16. FUTURE RESEARCH NEEDS

Fowler, Bruce A. Dr. Fowler began his scientific career at the National Institute of Environmental Health Sciences prior to becoming Director of the University of Maryland System-wide Program in Toxicology and Professor at the University of Maryland School of Medicine. He then served as Associate Director for Science in the Division of Toxicology and Environmental Medicine at Agency for Toxic Substances and Disease Registry (ATSDR). He is currently a private consultant and Co-owner of Toxicology Risk Assessment Consulting Services (TRACS), LLC. In addition, Dr. Fowler serves as an Adjunct Professor, Emory University Rollins School of Public Health and Presidents Professor of Biomedical Sciences, Center for Alaska Native Health Research (CANHR) at the University of Alaska- Fairbanks. Dr. Fowler, is an internationally recognized expert on the toxicology of metals and has served on a number of State, National and International Committees in his areas of expertise. These include the Maryland Governor's Council on Toxic Substances (Chair), various National Academy of Sciences / National Research Council Committees, including the 1993 landmark NAS/NRC Report on "Measuring Lead Exposure in Infants Children and Other Sensitive Populations” for which he served as the Committee Chair. He has also served on a number of review committees of the National Institutes of Health, the USEPA Science Advisory Board and the Fulbright Scholarship review committee for Scandinavia (Chair, 2000-2001). In 2016, he became an Inaugural Member of the Fulbright 1946 Society and in 2018 became a member of the Fulbright Association Board of Directors. He has also served as a temporary advisor to the World Health Organization (WHO) and on working groups of the International Agency for Research Against Cancer (IARC) for a number of toxicology and risk assessment issues. He is presently appointed as a member of the Joint FAO/WHO Expert Committee on Food Additives (JECFA) for the period 2016-2020. Dr.

"Computational Toxicology is big and it is clever!...The book is easy to read with a wealth of easy to follow figures and an abundance of references.it offers readers a good perspective of what is currently achievable with computational toxicology and what is on the horizon. This book certainly has a place in most libraries."--btsNews, June 2014 "This collection reviews the state of the science in computer models for assessing human risk from chemical exposure and identifies specific applications that have enhanced the response to a defined risk assessment challenge.Practical translation of computational methods for risk assessment, computational translation and integration of test data to meet risk assessment goals, and computational translation of data from nonmammalian species. are also discussed."--ProtoView.com, February 2014 "ICF International experts authored this essential reference on the translation of computational toxicology data into information that can be used for more informed risk-assessment decision making. The book provides an updated summary of the state-of-the-art science in the field of computational toxicology methods and offers examples of applications to risk assessment."--ICF International online, 2013 "This collection reviews the state of the science in computer models for assessing human risk from chemical exposure and identifies specific applications that have enhanced the response to a defined risk assessment challenge. The 11 contributions describe physiologically based pharmacokinetic.models for simulating dose metrics in sensitive subpopulations, a dynamic systems model of rat liver homeostasis, the quantitative structure-activity relationship. tool for simulating necessary endpoints, and omics biomarker discovery."--Reference & Research Book News, December 2013 "The new book on Computational Toxicology edited by Dr. Bruce Fowler is a timely publication. It presents, in a well-organized and concise