Concise Guide to Hematology

List of Contributors ixPreface xii1 Introduction to Hematology 1Alvin H. Schmaier2 Hematopoiesis 6Yuan Lin and Stanton L. Gerson3 Red Blood Cell Biochemistry and Physiology 16Kevin T. McDonagh4 Anemia: Clinical Approach 24Peter W. Marks5 Iron Deficiency 35Alice Ma6 Vitamin-B12 (Cobalamin) and Folate Deficienc, 44Asok C. Antony7 Congenital Hemolytic Anemia, 62Archana M. Agarwal and Josef T. Prchal8 Acquired Hemolytic Anemia, 75Scott D. Gitlin9 Overview of Hemostasi, 91Alvin H. Schmaier10 Approach to the Bleeding Patien, 103Alvin H. Schmaier11 Congenital Bleeding Disorder, 112Anjali A. Sharathkumar and Steven W. Pipe12 Acquired Bleeding Disorder, 131Howard A. Liebman13 Platelet Function in Hemostasis and Inherited Disorders of Platelet Number and Function 140A. Koneti Rao and David W. Essex14 Acquired Thrombocytopenia 154Theodore E. Warkentin and Andrew E. Warkentin15 Thrombosis and Anticoagulation 174Alvin H. Schmaier16 Myeloid Cell Physiology and Disorders 184Alvin H. Schmaier, Lilli M. Petruzzelli, Niels Borregaard and Laurence A. Boxer17 Bone Marrow Structure and Diagnostic Testing 197Howard J. Meyerson and Hillard M. Lazarus18 Myeloproliferative Neoplasms and Myelodysplastic Syndromes 220Gabriela Motyckova and Richard M. Stone19 Acute Leukemia 235Tsila Zuckerman and Jacob M. Rowe20 Classifi cation of Lymphoma 251Yi-Hua Chen and Amy Chadburn21 Clinical Evaluation and Management of Lymphoma 268Makiko Ban-Hoefen, Jonathan W. Friedberg and Richard I. Fisher22 Plasma Cell Disorders 287Sumit Madan and Philip R. Greipp23 Pediatric Hematology 307Sanjay P. Ahuja24 Blood Banking 319Lawrence Tim Goodnough25 Transfusion Therapy 332Beth H. Shaz and Christopher D. Hillyer26 Hematopoietic Cell Transplantation 344Hillard M. Lazarus27 Atlas of Hematology Slides 363Alvin H. SchmaierIndex 389

Dr Alvin H. Schmaier is the Robert W. Kellermeyer Professor of Hematology and Oncology and Chief of Hematology and Oncology at Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio. He is formally a Professor at Temple University and the University of Michigan. At both institutions he was Director of the Coagulation Laboratory and at the University of Michigan he was course Director of the Hematology sequence from 1999-2005. His research area is in the field of hemostasis, thrombosis, and vascular biology. He was an Associate Editor of Thrombosis and Haemostasis and serves as an Advisor to the Journal of Thrombosis and Haemostasis. He is the President of Thromgen, Inc, an early-stage cardiovascular pharmacology company. He is the author of 114 peer-reviewed papers, 70 review articles, 13 editorials, 1 book and 8 patents.Dr Hillard Lazarus is a tenured full Professor of Medicine in the Division of Hematology-Oncology and the Director of the Stem Cell Transplant Program at the Ireland Cancer Center, University Hospitals Case Medical Center. Dr Lazarus was the Chair of the Stem Cell Transplant Committee of the Eastern Cooperative Oncology Group (ECOG) from the time it was established in the mid-1980s. Dr Lazarus has been identified as an Outstanding Physician in national and local surveys. He has over 250 publications in peer-reviewed journals, 43 book chapters and 50 review articles. He is Co-Editor of the journal Bone Marrow Transplantation and also is an editor of three textbooks in the field of blood and bone marrow transplantation, hematologic malignancies, and supportive care for cancer patients.