Correlation of Hepcidin Level in Major Thalassemia
Correlation of Hepcidin Level with Insulin Resistance and Endocrine Glands Function in Major Thalassemia
(Sprache: Englisch)
Background. Hepcidin is a master regulator of iron metabolism that inhibits the transport of iron out of enterocytes and macrophages. Thalassemia major (TM) is associated with some of the endocrine disorders. However, studies have yet to be conducted on the...
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Background. Hepcidin is a master regulator of iron metabolism that inhibits the transport of iron out of enterocytes and macrophages. Thalassemia major (TM) is associated with some of the endocrine disorders. However, studies have yet to be conducted on the correlation of hepcidin with hormone levels and insulin resistance (IR) in patients with TM.Objectives. In the present study, the correlation of hepcidin level with some endocrine and biochemical parameters was investigated to determine the factors that mainly affect hepcidin correlation in patients with thalassemia. These factors include hormones, iron status, and IR parameters.Material and Methods. Hepcidin and other measured biochemical parameters were compared between the TM patients (100) and healthy children (37).Results. Serum thyroid-stimulating hormone (TSH) was positively correlated (p < 0.05) with hepcidin, iron, and ferritin. T4 hormone was correlated with ferritin only.
Autoren-Porträt von Manal AL-Khakani, Mahmood Al-Kindi, Hussein Al-Hakeim
AL-Khakani, ManalDr. Manal F. AL-Khakani (PhD) Biochemistry Department of Chemistry, College of Science, Kufa University, Iraq
Bibliographische Angaben
- Autoren: Manal AL-Khakani , Mahmood Al-Kindi , Hussein Al-Hakeim
- 56 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Verlag: Noor Publishing
- ISBN-10: 620078163X
- ISBN-13: 9786200781635
Sprache:
Englisch
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