Determination of some Isoflavonoids against mammary cell carcinoma
To evaluate the anti-cancer activity of Limonia acidissima L. used traditionally for various malignant diseases
(Sprache: Englisch)
To evaluate the anti-cancer activity of Limonia acidissima Linn (Rutaceae) which has long been used traditionally for various infectious and malignant diseases. The fruit extract of Limonia acidissima Linn was obtained by macerating 3 times with methanol...
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To evaluate the anti-cancer activity of Limonia acidissima Linn (Rutaceae) which has long been used traditionally for various infectious and malignant diseases. The fruit extract of Limonia acidissima Linn was obtained by macerating 3 times with methanol and then concentrating it at reduced pressure. Bioassay of the extract was carried out to assess the anticancer activity. Breast cancer cell lines, SKBR3 and MDA MB435, were used for in-vitro cell proliferation, cell viability assay, and cell cycle analysis of the extract.Results: Bioassay of the extract of Limonia acidissima Linn. showed that a fraction (fraction 3) of the ethanol extract had anticancer activity against SKBR3 and MDA-MB435 human breast cancer cells. The effective dose (ED50) of Limonia acidissima Linn. fraction 3 was 56.1 and 30.6 mig/ml for SKBR3 and MDA-MB435, respectively. After 48 h of exposure, this fraction (100 mig/ml) significantly reduced cell proliferation in both cancer cell lines. In MDA-MB435 cells,cell cycle analysis showed that fraction 3induced the accumulation of cells in G2/M phase, but no significant change in cell cycle was detected in SKBR3 cells.
Autoren-Porträt von Jyoshna Rani Dash, Gurudutta Pattnaik, Biswakanth Kar
Dash, Jyoshna RaniMs. Jyoshna Rani Dash, M.pharm is working as a research scholar at the School of Pharmacy and Life Sciences, Centurion University of Technology and Management, Bhubaneswar, Odisha.
Bibliographische Angaben
- Autoren: Jyoshna Rani Dash , Gurudutta Pattnaik , Biswakanth Kar
- 2020, 64 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Verlag: LAP Lambert Academic Publishing
- ISBN-10: 6203029386
- ISBN-13: 9786203029383
Sprache:
Englisch
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