Directed Evolution
of the Aspergillus niger Epoxide Hydrolase
(Sprache: Englisch)
Darwinian Evolution of an enzyme?? You might wonder, what's this??Genetic Evolution of a biocatalyst, scientifically known as "directed evolution", has emerged in last decade thanks to great advances in molecular biology as a very powerful tool to...
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Darwinian Evolution of an enzyme?? You might wonder, what's this??Genetic Evolution of a biocatalyst, scientifically known as "directed evolution", has emerged in last decade thanks to great advances in molecular biology as a very powerful tool to genetically "manipulate" an enzyme, either to improve enzyme properties, to switch the selectivity or to create a completely new catalyst.Epoxides are versatile building blocks for natural product synthesis. Quoting Prof. Seebach: "If carbonyl compounds have been said to be virtually the backbone of organic synthesis, the epoxides correspond to at least one of the main muscles", this emphasized the importance of these compounds. Epoxide hydrolases are useful biocatalysts to obtain optically enriched epoxides.This work applied directed evolution as a strategy to improve the enantioselectivity of an epoxide hydrolase. Different selection and screening methods were established... What about the final result? Take a look, you will findout!
Autoren-Porträt von Li-Wen Wang
Wang Li-WenLi-Wen Wang was born in Taipei, Taiwan, on March 29th 1976. After obtaining her B.S. and M.Sc. in Chemical Engineering at the National Cheng-Kung University in Taiwan, she was granted a DAAD stipend to pursue her Ph.D. study at the Max-Planck-Institut fuer Kohlenforschung in Muelheim an der Ruhr, Germany.
Bibliographische Angaben
- Autor: Li-Wen Wang
- 2008, 100 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Verlag: VDM Verlag Dr. Müller e.K.
- ISBN-10: 3639060156
- ISBN-13: 9783639060157
Sprache:
Englisch
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