Discrimination of Chiral Compounds Using NMR Spectroscopy
(Sprache: Englisch)
This book provides a comprehensive discussion of the use of NMR spectroscopy for chiral discrimination. One goal is to show the full scope of the work that has beendone in this area as a way of guiding future investigations into other potential chiral...
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This book provides a comprehensive discussion of the use of NMR spectroscopy for chiral discrimination. One goal is to show the full scope of the work that has beendone in this area as a way of guiding future investigations into other potential chiral reagents for use in NMR spectroscopy. It describes the systems that have been developed and the utility of these. More importantly, the book provides a comprehensive guide for investigators who may be considering using NMR spectroscopy to determine enantiomeric excess (ee) or assign the absolute configuration of a compound under study. While the book mentions all of the available chiral systems that have been reported in the literature for use in NMR spectroscopy, it focuses primarily on the systems that are commercially available. The book catalogs the range of compounds for which different reagents have been shown to be effective, and the extent to which they successfully discriminate the compounds being studied. This allows comparisons of the reagents and enables investigators to make recommendations on which reagents are most likely to be effective for particular types of compounds. Throughout the book, where appropriate, the author provides experimental strategies for using the reagents that are likely to improve the quality of results.
Klappentext zu „Discrimination of Chiral Compounds Using NMR Spectroscopy “
A comprehensive overview of the use of NMR spectroscopy for chiral discriminationDiscrimination of Chiral Compounds Using NMR Spectroscopy concisely covers the broad array of reagents that make it possible to determine the optical purity and assign the absolute configuration of many classes of compounds. It describes chiral NMR derivatizing agents, solvating agents, metal-based reagents, and liquid crystals and discusses the range and types of compounds for which they can be used for analysis. After an overview of chiral reagents and methodologies, this reference:
Includes comprehensive coverage of the chiral reagents that have been reported
Catalogs the range of compounds for which different reagents have been shown to be effective
Includes specialty categories such as liquid crystals, ionic liquids, and the formation of chiral aggregates from achiral building blocks that do not fit into the broader categories
Offers experimental strategies for using the reagents that are likely to improve the quality of the results
This guide describes the various systems and their overall utility, but goes further to show the full scope of the field as a way of guiding investigations into the optimal chiral reagents for use in NMR spectroscopy. It's a practical reference for organic chemists in the pharmaceutical industry, academia, and other areas, NMR spectroscopists, and researchers involved in the isolation and structure determination of natural products.
Inhaltsverzeichnis zu „Discrimination of Chiral Compounds Using NMR Spectroscopy “
Chapter 1. IntroductionChapter 2. Aryl-containing Carboxylic Acids
Chapter 3. Other Carboxylic Acid-Based Reagents
Chapter 4. Hydroxyl- and Thiol-Containing Reagents
Chapter 5. Amine-based Reagents
Chapter 6. Miscellaneous Organic-Based Chiral Derivatizing and Solvating Agents
Chapter 7. Reagents Incorporating Phosphorus, Selenium, Boron, and Silicon Atoms
Chapter 8. Host Compounds as Chiral NMR Discriminating Agents
Chapter 9. Chiral Discrimination with Metal-Based Reagents
Chapter 10. Chiral NMR Discrimination with Highly Ordered Systems
Autoren-Porträt von Thomas J. Wenzel
Thomas J. Wenzel, PHD, is the Charles A. Dana Professor of Chemistry at Bates College in Lewiston, Maine. He has received research and educational grants from the National Science Foundation, Research Corporation, the Petroleum Research Fund, the Camille and Henry Dreyfus Foundation, and the Pittsburgh Conference and Exhibition. His most recent research focuses on the development of chiral NMR shift reagents.
Bibliographische Angaben
- Autor: Thomas J. Wenzel
- 2007, 1. Auflage, 576 Seiten, Maße: 16,1 x 24,2 cm, Gebunden, Englisch
- Verlag: Wiley & Sons
- ISBN-10: 0471763527
- ISBN-13: 9780471763529
Sprache:
Englisch
Pressezitat
"...a foremost literature resource for NMR-based enantiodiscrimination." ( Journal of Medicinal Chemistry , October 18, 2007)
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