Damian, M: DNA Bending Molecules for Improvement of Cisplati
(Sprache: Englisch)
Modification of the anticancer drug cisplatin was investigated by designing hybrid molecules of the platinum moiety with peptide motifs. New cisplatin analogs were synthesized and DNA interaction studies were performed. A mixture of cationic metal complexes...
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Modification of the anticancer drug cisplatin was investigated by designing hybrid molecules of the platinum moiety with peptide motifs. New cisplatin analogs were synthesized and DNA interaction studies were performed. A mixture of cationic metal complexes with positively charged peptides was chosen as the strategy to facilitate DNA binding induced by DNA preassociation and bending of the DNA target.
Bibliographische Angaben
- Autor: Mariana Simona Damian
- 156 Seiten, Maße: 14,7 x 21,1 cm, Kartoniert (TB), Englisch
- Verlag: Cuvillier Verlag
- ISBN-10: 3869555807
- ISBN-13: 9783869555805
- Erscheinungsdatum: 02.12.2010
Sprache:
Englisch
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