Drug Discovery in Pancreatic Cancer
Models and Techniques
(Sprache: Englisch)
There have been tremendous advances in cancer drug discovery, and in the area of molecular and genetic models and technologies. In this book, experts describe the latest developments in the application of these models and technologies in pancreatic cancer.
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There have been tremendous advances in cancer drug discovery, and in the area of molecular and genetic models and technologies. In this book, experts describe the latest developments in the application of these models and technologies in pancreatic cancer.
Klappentext zu „Drug Discovery in Pancreatic Cancer “
Pancreatic cancer is the fourth leading cause of cancer death in the United States. Every year, about 33,700 people in the United States will be diagnosed with pancreatic cancer and over 32,000 patients will die from the disease. The median survival of patients with advanced pancreatic cancer is about 6-months. This dismal picture of pancreatic cancer is mainly due to the lack of early diagnosis and effective treatment for patients with advanced disease. To increase the survival rate of pancreatic cancer patients, better tumor markers for diagnosis and new molecular targets for drug development are desperately needed. A lot of effort has been made in searching for pancreatic cancer-causing genes or genes associated with progression of malignant behavior in pancreatic cancer. As a result, alterations in the expression of several cancer-related genes have been identified in pancreatic tumors. The identification and characterization of these cancer-related genes have significantly increased our understanding of pancreatic cancer development, but unfortunately the treatment of pancreatic cancer has not advanced as much in the past 20 years.Over the past decade, tremendous advances have been made in the field of cancer drug discovery, particularly, in the area of molecular and genetic models and technologies. Many of those advanced models and technologies have been applied to the drug discovery processes for pancreatic cancer. In this book, a team of experts will describe the latest development in the application of these models and technologies in pancreatic cancer. The authors include basic researchers as well as clinicians who work in the front-line of the war against pancreatic cancer and have the first-hand experience on these cutting-edge tools and techniques. The book can be divided into two general areas: 1) model systems and 2) genomics and proteomics tools. In recent years there have been a lot of advances in the model systems for pancreatic cancer,
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including the further characterization of normal and cancerous pancreatic cell lines, the establishment of transgenic mouse models that recapitulate the initiation and progression of human pancreatic cancer, the development of a new xenograft model system for the evaluation of novel agents, and the establishment of a zebrafish pancreatic cancer model. The first four chapters of the book will be devoted to these models. The advances in genomics and proteomics research have made a major impact in cancer drug discovery. A number of these -omics-based tools and techniques have been applied in the pancreatic cancer drug discovery. Chapters 5-9 of the book will discuss techniques for genome-wide examination of gene expression, copy number, methylation, function and regulation. Chapters 10-11 will discuss in situ techniques for studying chromosomal and gene copy number abnormalities as well protein expression changes in cancer samples. Chapters 12-14 will focus on techniques for global examination of protein expression levels in biospecimens obtained from pancreatic cancer patients. Cancer drug discovery has become more and more target-centric.
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Inhaltsverzeichnis zu „Drug Discovery in Pancreatic Cancer “
Chapter 1: Pancreatic cancer cell line modelsSteven Warner, Ph.D
Translational Genomics Research Institute
Division of Clinical Translational Research
Chapter 2: Pancreatic cancer xenograft models
Manuel Hidalgo, M.D., Ph.D
Johns Hopkins University School of Medicine
Chapter 3: Pancreatic cancer transgenic mouse models
David A. Tuveson M.D., Ph.D
Cancer Research UK Cambridge Research Institute
Chapter 4: Pancreatic cancer zebra fish models
Steven Leach, M.D
Division of Surgical Oncology
Johns Hopkins University School of Medicine
Chapter 5: DNA microarray expression profiling
Charles Gawad, M.D
School of Medicine
University of California at Los Angeles
Chapter 6: Array CGH profiling
Robert Lucito, Ph.D
Cold Spring Harbor Laboratory
Chapter 7: High throughput siRNA
Spyro Mousses, Ph.D
Division of Pharmaceutical Genomics
Translational Genomics Research Institute
Chapter 8: miRNA profiling
Glen J. Weiss, M.D
University of Colorado Health Science Center
Department of Hematology and Medical Oncology
Chapter 9: Methylation detection and epigenetics
Bernard W. Futscher, Ph.D
Arizona Cancer Center
Chapter 10: Tissue microarray based IHC and FISH
Anirban Maitra, MBBS
The Sol Goldman Pancreatic Cancer Research Center
Johns Hopkins University School of Medicine
Chapter 11: Spectral Karyotyping (SKY) and M-FISH
Thomas R. Dennis, Ph.D
Translational Genomics Research Institute
Chapter 12: Proteomics analysis of serum and pancreatic juice
Michael Goggins, M.D
The Sol Goldman Pancreatic Cancer Research Center
The Johns Hopkins University School of Medicine
Chapter 13: Glycomics analysis of serum and pancreatic juice samples
J. Michael Pierce, Ph.D
University of Georgia
Director, UGA Cancer Center
Chapter 14: Protein arrays for pancreatic cancer research
Raoul Tibes, M.D
Division of Pharmaceutical Genomics
Translational Genomics Research Institute
Chapter 15: Vaccines for pancreatic cancer
Dan A.
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Laheru, M.D
Buntings Blaustein Cancer Research Building Room G89
Chapter 16: Molecular imaging of small animals
Robert J. Gillies, Ph.D
Department of Radiology
Arizona Cancer Center, MRB 138
Chapter 17 : Development of pharmacodynamic endpoint models for the evaluation of clinical activities of targeted therapeutics
Amanda Baker, Ph.D
Arizona Cancer Center
Buntings Blaustein Cancer Research Building Room G89
Chapter 16: Molecular imaging of small animals
Robert J. Gillies, Ph.D
Department of Radiology
Arizona Cancer Center, MRB 138
Chapter 17 : Development of pharmacodynamic endpoint models for the evaluation of clinical activities of targeted therapeutics
Amanda Baker, Ph.D
Arizona Cancer Center
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Bibliographische Angaben
- 2014, 2010, XIX, 297 Seiten, Maße: 15,5 x 23,5 cm, Kartoniert (TB), Englisch
- Herausgegeben: Haiyong Han, Paul Grippo
- Verlag: Springer, Berlin
- ISBN-10: 1489982752
- ISBN-13: 9781489982759
Sprache:
Englisch
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