Emerging Targets in Antibacterial and Antifungal Chemotherapy

Contributors; Preface; Part I: Antibacterial chemotherapy: Historical perspectives of approaches to antibiotics discovery-- Akira Imada and Kunimoto Hotta; Bacterial pathogens for the 90's: a case for new drug development-- George L. Drusano; DNA synthesis-- Charles S. McHenry; RNA synthesis in bacteria: mechanism and regulation of discrete biochemical events at initiation and termination-- Asis Das, Joseph DeVito, Jason Sparkowski and Frederick Warren; Bacterial cell division-- Joe Lutkenhaus; Fatty acid biosynthesis-- Suzanne Jackowski; Protein secretion in bacteria: a chemotherapeutic target?-- Rajeev Misra and Thomas J. Silhavy; Cytosolic enzymes in peptidoglycan biosynthesis as potential antibacterial targets-- W. Stephen Faraci; Strategies in Beta-lactam design-- Frank Neuhaus and Nafsika H. Georgopapadakou; Lipid A biosynthesis-- Jack Coleman; Compromising the protective barrier of the Gram-negative bacterial cell surface-- Catherine P. Reese and Joanna Clancy; Bacterial virulence factors as targets for chemotherapy-- Sarah H. Highlander and George M. Weinstock; Part II: Antifungal chemotherapy: Invasive fungal infections: problems and challenges for developing new antifungal compounds-- Thomas J. Walsh; Topoisomerase II inhibitors: prospects for new antifungal agents-- D. E. Jackson, D. P. Figgitt and S. P. Denyer; Functions for sterols in yeast membranes-- Leo W. Parks, R. Todd Lorenz and Warren M. Casey; Biochemical aspects of ergosterol biosynthesis inhibition-- Keith Barrett-Bee and Neil Ryder; Rationally designed inhibitors of sterol biosynthesis-- A. C. Oehlschlager and E. Czyzewska; Chitin synthase as a chemotherapeutic target-- Nafsika H. Georgopapadakou; Glucan biosynthesis in fungi and its inhibition-- Jan S. Tkacz; Virulence-associated mannoproteins in Candida albicans-- Richard A. Calderone and Makiko Fukayama; Screening for antifungal activity-- John F. Ryley and KeithJ. Barrett-Bee; Chemotherapeutic targets in Pneumocystis carinii-- Gregg Y.

This is a book which will be invaluable to a variety of physicians and basic scientists working in the field of antimicrobial chemotherapy. - R C Moellering, Physician-in-Chief, Harvard Medical School; This is a book which will be invaluable to a variety of physicians and basic scientists working in the field of antimicrobial chemotherapy. - R C Moellering, Physician-in-Chief, Harvard Medical School; This is a book which will be invaluable to a variety of physicians and basic scientists working in the field of antimicrobial chemotherapy. - R C Moellering, Physician-in-Chief, Harvard Medical School