Encyclopedia of Spectroscopy and Spectrometry

termed metabonomics. George Tranter is a Director of Chiralabs Ltd., a company he co-founded in 2002 specializing in the analysis and investigation of pharmaceuticals and biopharmaceuticals, especially in terms of their chirality, structure, crystallisation and physicochemical behaviour. He obtained his BSc and PhD at the Chemistry Department of King's College, University of London, UK (1977-83), then joined the Theoretical Chemistry Department of the University of Oxford, specializing in chiral phenomena and optical spectroscopies. From 1987 he held senior R&D positions in the pharmaceutical industry (the Wellcome Foundation and GlaxoWellcome), before returning to academia in 2000. Until 2006 he led the Biospectroscopy Centre of Imperial College London and subsequently was Senior Research Fellow of the Department of Chemistry, University of Oxford, maintaining strong collaborative links with the pharmaceutical and biotechnology industries throughout. He is a recognised authority in chirality and the spectroscopic / physicochemical features of drugs and biopharmaceuticals, a co-inventor of the internationally award-winning rational crystallisation screening technology CrystalGEM(r) and is a named inventor on drug patents. He has published widely in the scientific literature, is an editor of the Encyclopedia of Spectroscopy and Spectrometry, has been a member of scientific journal editorial boards and appeared on radio and television programmes in the UK and abroad. He is also a member of various scientific advisory panels, has been a Visiting Fellow of the National Physical Laboratory (UK), and is a key partner in collaborations that bring together the biopharmaceutical industry, academia and governmental institutions to investigate and validate biopharmaceutical structure and function. He is a Fellow of the Royal Society of Chemistry (FRSC), a Chartered Chemist (CChem), and a European Chartered Scientist (CSi). His particular interests are in the rational discovery of new therapeutics, with a passion for the role chirality plays in nature, from the molecular level through to macroscopic structures and beyond. Research and development activities also include the generation of novel technologies to help rationalise poorly understood phenomena. He is also an enthusiastic underwater spectroscopist-photographer studying the unusual spectroscopic characteristics of marine creatures. Dr. Koppenaal (PhD, University of Missouri Columbia) manages the Biological Separations & Mass Spectrometry group within the Biological Sciences Division of the Fundamental & Computational Sciences Directorate at Pacific Northwest National Laboratory. He manages 65 staff members in the development of high-resolution separations and mass spectrometry and their applications in biological research. The current research emphasis is in the area of proteomics - the study of the entire complement of proteins expressed in a cell under a specific set of conditions at a specific time. Dr. Koppenaal served as interim Chief Research Officer (CRO) for PNNL from June 2006 through September 2007. From 2003-2006, he managed the Macromolecular Structure and Dynamics group within the Biological Sciences Division. He managed this same group while Associate Director of the W.R. Wiley Environmental Molecular Sciences Laboratory from 1998-2003. In these roles, Dr. Koppenaal oversaw the development, installation, and commissioning of the world's first wide-bore 900 MHz NMR spectrometry system (at that time the highest field NMR in the world). Dr. Koppenaal's recent research includes the development of new types of mass spectrometry instrumentation and MS detectors based on ion-sensitive arrays (in collaboration with colleagues at the University of Arizona and Indiana University). This research may well provide the basis for a truly simultaneous, "all-the-signal, all-the-time" detector for elemental mass spectrometry, and has recently been highlighted in an Analytical Chemistry 'A' page review article. Another recent interest has taken Dr. Koppenaal into the field of metallomics. He helped introduce the elemental analysis community to this emerging new field and is currently active in the development of new high-resolution instrumentation and methods for the characterization of the metallome. A former American Chemical Society Analytical Chemistry Division Chair, he is a Fellow of both the American Association for the Advancement of Science and the Royal Society of Chemistry (UK).

spectrometry. Entries reprinted from the first edition were not updated at all. While newer entries often bring the information up-to-date, some of the older entries remain outdated, particularly in their bibliographies. Overall, this encyclopedia gathers vast amounts of information into a single work. Though imperfect, it is useful for working chemists and for others, including advanced students, as a reference in spectroscopy and spectrometry from ATR to Zeeman. " Summing Up: Recommended. Upper-division undergraduates through professionals/practitioners. -- E. J. Chang, York College -CHOICE, June 2011 Vol. 48 No. 10