Endosymbiotic Archaea, Autoimmunity and Warburg Phenotype
Climate Change Related Tropical Syndromes
(Sprache: Englisch)
Climate change leads to endosymbiotic archaeal growth. Archaea has got methanogenic archaeal selenoproteins and uses the cellular selenium reserves and depletes selenium from the human system. This leads on to decreased cholesterol synthesis. Archaea also...
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Climate change leads to endosymbiotic archaeal growth. Archaea has got methanogenic archaeal selenoproteins and uses the cellular selenium reserves and depletes selenium from the human system. This leads on to decreased cholesterol synthesis. Archaea also has got cholesterol oxidase activity and uses cholesterol for its energetics. The depletion of cholesterol leads to increased production of HMG CoA reductase enzyme, the rate limiting step in cholesterol synthesis. The increased production of HMG CoA reductase leads to defective processing of the HMG CoA reductase molecule making it antigenic. The inhibition of HMG CoA reductase by antiHMG CoA reductase antibody inhibits the isoprenoid pathway and synthesis of CoQ producing mitochondrial dysfunction. This leads to increased glycolytic activity and generation of the Warburg phenotype. Endosymbiotic archaea mediated autoimmune mitochondrial dysfunction and Warburg phenotype can lead on to climate change related tropical syndromes.
Autoren-Porträt von Ravikumar Kurup
Kurup, RavikumarDr Ravikumar Kurup is the Director of the Metabolic Disorders Research Centre, Trivandrum. His areas of interest are Symbiotic Biology and Metabolic Medicine.Kurup, RavikumarDr Ravikumar Kurup is the Director of the Metabolic Disorders Research Centre, Trivandrum. His areas of interest are Symbiotic Biology and Metabolic Medicine.
Bibliographische Angaben
- Autor: Ravikumar Kurup
- 2019, 84 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Verlag: LAP Lambert Academic Publishing
- ISBN-10: 6200301077
- ISBN-13: 9786200301079
Sprache:
Englisch
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