Enzyme Chemistry

Contributors.- Preface.- 1 Infant Enzyme Chemistry.- 2 The Mechanistic Basis of Enzyme Catalysis.- 2.1 The mechanistic approach.- 2.2 Concepts of catalysis.- 2.3 Describing a mechanism.- 2.4 Kinetics: the measure of catalysis.- 2.5 Stereochemistry and specificity.- 2.6 Stereochemistry and mechanism.- 2.7 Entropy and enzymic catalysis.- 2.8 Acid-base catalysis.- 2.9 Linear free-energy relationships and enzymic reactions.- 2.10 Enzymic efficiency.- 2.11 Examples of intramolecular catalysis.- 2.12 Transition state analogues.- 2.13 Multiple binding sites.- 2.14 Biomimetic chemistry.- 2.15 Conclusion.- References.- 3 Chemical Models of Selected Coenzyme Catalyses.- 3.1 Introduction.- 3.2 Model investigations of nicotinamide coenzymes.- 3.3 Flavin catalyses.- 3.4 Catalyses relating to vitamin B1 and analogues.- 3.5 Pyroxidal catalyses.- 3.6 Catalyses of thiol coenzymes.- 3.7 Conclusion.- References.- 4 Selectivity in Synthesis - Chemicals or Enzymes?.- 4.1 Introduction.- 4.2 Problems overcome.- 4.3 Logic and analogy in the synthetic uses of enzymes and micro-organisms.- 4.4 Enzymes and chemical reagents in 'competition'.- 4.5 Late-stage functional-group modification.- 4.6 Biomimetic chemistry in synthesis.- 4.7 Enzymes in organic solvents.- 4.8 Advances in protein chemistry and molecular biology.- 4.9 Conclusions.- References.- 5 Enzymes As Targets for Drug Design.- 5.1 Introduction.- 5.2 Case studies in drug discovery.- 5.3 Recent developments and their application to inhibitor design.- References.- 6 The Impact of Metal Ion Chemistry on Our Understanding of Enzymes.- 6.1 Introduction and general chemical principles.- 6.2 The transition elements iron and copper.- 6.3 Transition metal ions.- 6.4 Main group elements.- 6.5 Some toxic metals.- 6.6 Metal ions as drugs.- 6.7 Modern physical methods.- 6.8 Conclusions 262 References.- 7 The Enzymology of The Biosynthesis of Natural Products.- 7.1 Introduction.- 7.2 Recent advances in the study of biosynthetic enzymes.- 7.3