Essential Developmental Biology
(Sprache: Englisch)
ESSENTIAL DEVELOPMENTAL BIOLOGY
Discover the foundations of developmental biology with this up to date and focused resource from two leading experts
The newly revised Fourth Edition of Essential Developmental Biology delivers the...
Discover the foundations of developmental biology with this up to date and focused resource from two leading experts
The newly revised Fourth Edition of Essential Developmental Biology delivers the...
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ESSENTIAL DEVELOPMENTAL BIOLOGYDiscover the foundations of developmental biology with this up to date and focused resource from two leading experts
The newly revised Fourth Edition of Essential Developmental Biology delivers the fundamentals of the developmental biology of animals. Designed as a core text for undergraduate students in their first to fourth years, as well as graduate students in their first year, the book is suited to both biologically based and medically oriented courses. The distinguished authors presume no prior knowledge of development, animal structure, or histology.
The new edition incorporates modern single cell transcriptome sequencing and CRISPR/Cas9, as well as other methods for targeted genetic manipulation. The existing material has also been reorganized to provide for easier reading and learning for students. The book avoids discussions of history and experimental priority and emphasizes instead the modern advances in developmental biology. The authors have kept the text short and focused on the areas truly central to developmental biology. Readers will benefit from the inclusion of such topics as:
* A thorough discussion of the groundwork of developmental biology, including developmental genetics, cell signaling and commitment, and cell and molecular biology techniques
* An exploration of major model organisms, including Xenopus, the zebrafish, the chick, the mouse, the human, Drosophila, and Caenorhabditis elegans
* A treatment of organogenesis, including postnatal development, and the development of the nervous system, mesodermal organs, endodermal organs, and imaginal discs in drosophila
* A final section on growth, stem cell biology, evolution, and regeneration
Perfect for undergraduate students, especially those preparing to enter teaching or graduate studies in developmental biology, Essential Developmental Biology will also earn a place in the libraries of those in the pharmaceutical
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industry expected to be able to evaluate assays based on developmental systems.
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Inhaltsverzeichnis zu „Essential Developmental Biology “
Preface, ixAbout the companion website, xi
Section 1: Groundwork, 1
1 The excitement of developmental biology, 3
Where the subject came from, 3
Impact of developmental biology, 4
Future impact, 5
2 How development works, 7
Ultrashort summary, 7
Gametogenesis, 10
Early development, 13
Growth and death, 19
3 Approaches to development: developmental genetics, 25
Developmental mutants, 25
Sex chromosomes, 27
Maternal and zygotic, 27
Genetic pathways, 28
Genetic mosaics, 30
Screening for mutants, 31
Cloning of genes, 32
Gain-and loss-of-function experiments, 32
Transgenesis, 32
Other gain-of- function techniques, 34
Targeted mutagenesis, 34
Other loss-of- function systems, 35
Gene duplication, 36
Limitations of developmental genetics, 37
4 Approaches to development: experimental embryology and its molecular basis, 39
Normal development, 39
Developmental commitment, 42
Criteria for proof, 48
Transcription factors, 48
Transcription factor families, 50
Other controls of gene activity, 51
Signaling systems, 51
Genetic regulatory networks, 57
5 Approaches to development: cell and molecular biology techniques, 61
Microscopy, 61
Optical techniques, 61
Confocal, multi-photon, and light sheet microscopes, 63
Image capture, 63
Anatomical and histological methods, 64
Microinjection, 66
Study of gene expression by molecular biology methods, 67
Study of gene expression by in situ methods, 72
Reporter genes, 75
Cell-labeling methods, 76
6 Cells into tissues, 81
Cells in embryos, 81
Cytoskeleton, 82
Small GTP-binding proteins,
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84
Extracellular matrix, 84
Cell movement, 85
Epithelial organization, 86
Morphogenetic processes, 88
Section 2: Major model organisms, 97
7 Major model organisms, 99
The big six, 99
Access and micromanipulation, 101
Genetics and genomes, 101
Relevance and tempo, 102
Other organisms, 102
8 Xenopus, 107
Oogenesis, maturation, and fertilization, 108
Normal development, 109
Fate maps, 114
Experimental methods, 115
Processes of regional specification, 119
9 The zebrafish, 135
Normal development, 135
Fate map, 140
Genetics, 141
Reverse genetic methods, 144
Embryological techniques, 145
Regional specification, 145
Other roles of the zebrafish, 150
10 The chick, 153
Normal development, 154
Fate map, 158
Regional specification of the early embryo, 159
Description of organogenesis in the chick, 164
11 The mouse, 173
Mammalian fertilization, 173
Normal development of the mouse, 177
Fate map, 184
Regional specification in the mouse embryo, 185
Transgenic mice, 190
Embryonic stem cells, 192
Knockouts and knock-ins, 192
Nuclear transplantation and imprinting, 196
X-inactivation, 196
Teratocarcinoma, 198
12 Human early development, 203
Human reproduction, 203
Preimplantation development, 205
Human embryonic stem cells, 207
Extracellular matrix, 84
Cell movement, 85
Epithelial organization, 86
Morphogenetic processes, 88
Section 2: Major model organisms, 97
7 Major model organisms, 99
The big six, 99
Access and micromanipulation, 101
Genetics and genomes, 101
Relevance and tempo, 102
Other organisms, 102
8 Xenopus, 107
Oogenesis, maturation, and fertilization, 108
Normal development, 109
Fate maps, 114
Experimental methods, 115
Processes of regional specification, 119
9 The zebrafish, 135
Normal development, 135
Fate map, 140
Genetics, 141
Reverse genetic methods, 144
Embryological techniques, 145
Regional specification, 145
Other roles of the zebrafish, 150
10 The chick, 153
Normal development, 154
Fate map, 158
Regional specification of the early embryo, 159
Description of organogenesis in the chick, 164
11 The mouse, 173
Mammalian fertilization, 173
Normal development of the mouse, 177
Fate map, 184
Regional specification in the mouse embryo, 185
Transgenic mice, 190
Embryonic stem cells, 192
Knockouts and knock-ins, 192
Nuclear transplantation and imprinting, 196
X-inactivation, 196
Teratocarcinoma, 198
12 Human early development, 203
Human reproduction, 203
Preimplantation development, 205
Human embryonic stem cells, 207
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Autoren-Porträt von Jonathan M. W. Slack, Leslie Dale
Professor Jonathan M.W. Slack is an emeritus professor of the University of Bath, UK, where he was Head of the Department of Biology and Biochemistry; and the University of Minnesota, USA, where he was director of the Stem Cell Institute. He is a member of the European Molecular Biology Organization and a ??Fellow of the Academy of Medical Sciences. He has published numerous research papers on developmental biology as well as five other books, including The Science of Stem Cells (Wiley-Blackwell 2018).Professor Leslie Dale is Professor of Developmental Biology at University College London, UK, where he was Head of Teaching for the Department of Cell and Developmental Biology. He teaches developmental biology to both undergarduate and medical students. For his PhD he studied regeneration in Drosophila imaginal discs and subsequently the development of Xenopus embryos.
Bibliographische Angaben
- Autoren: Jonathan M. W. Slack , Leslie Dale
- 2021, 4. Aufl., 544 Seiten, Maße: 21,6 x 40 cm, Kartoniert (TB), Englisch
- Verlag: Wiley & Sons
- ISBN-10: 1119512859
- ISBN-13: 9781119512851
- Erscheinungsdatum: 18.11.2021
Sprache:
Englisch
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