Essentials of Restenosis

Pathophysiology and Diagnosis.- Unraveling the Complex Process of Restenosis From Bench to Bedside.- Epidemiology and Pathogenesis of Restenosis.- Clinical Presentation of Restenosis.- Pathological Anatomy of Restenosis.- The Influence of Shear Stress on Restenosis.- The Immune System in the Pathogenesis of Vascular Proliferative Disease.- Animal Restenosis Models.- Genetic Basis of Restenosis.- The Genomics of Restenosis.- Gene-Expression Profiling and Restenosis.- Proteomics and Restenosis.- Contribution of Circulating Progenitor Cells to Vascular Repair and Lesion Formation.- Cell Cycle Regulators and Vascular Proliferative Diseases.- Arterial Remodeling.- The Role of eNOS in Vascular Diseases.- Diagnosis of Restenosis.- The Use of Pressure Gradient in the Diagnosis of Restenosis.- The Use of Radio Isotopes in the Diagnosis of Vascular Proliferative Disease.- Magnetic Resonance Imaging for Restenosis.- Coronary Imaging With Multislice Spiral Computed Tomography.- Therapy of Restenosis.- Pharmacotherapy of Restenosis.- Brachytherapy.- Preclinical Data of Eluting Stents.- Clinical Data of Eluting Stents.- Biodegradable Stents.- Biotechnology in the Treatment of Restenosis.- Vascular Gene Therapy.- Antisense and ODN Transcription Factors in the Treatment of Vascular Proliferative Disease.- Cell Cycle Approaches to the Treatment of In-Stent Restenosis.- Local Gene and Cell Delivery Devices.

From the reviews:



"This is a comprehensive review of the problem of restenosis, from the basic science to clinical management. ... The audience includes interventional cardiology fellows and interventional cardiologists. The book describes the difficulties that cardiologists face trying to prevent and manage restenosis. ... Each chapter includes extensive references. This is a complete, state-of-the-art review of restenosis, covering all aspects of restenosis from pathophysiology to therapeutic management. The authors are leaders in interventional cardiology with extensive clinical experience in the field." (Adriana Maria Rosario, Doody's Review Service, December, 2007)

"A multiauthored, comprehensive compendium of virtually all aspects of the restenotic process after balloon- or stent-induced arterial injury. ... The text is written by a blueribbon panel of authors who provide an in-depth coverage of the topics. Many of the clinical chapters offer an excellent historical perspective on the problem of restenotis. ... Recommended Readership: Interventional (clinical and research) cardiologists and interventional fellows." (John F. Bresnahan, Mayo Clinic Proceedings, Vol. 83 (4), April, 2008)