Experimental and Clinical Effects of L-Asparaginase

Opening Remarks.- I. L-Asparaginase and the Asparagine Metabolism.- Asparaginase and Cancer - Yesterday and Today.- L-Asparaginase: Early Findings and Current Studies on the Metabolism of L-Asparagine in Lymphoma Cells.- Studies on the Control of Asparagine Biosynthesis in Mamalian Tissues.- II. Preparative Aspects.- Isolation and Crystallisation of L-Asparaginase from E. coli.- Biochemical Characterization of L-Asparaginases from E. coli.- Some Physicochemical Aspects of L-Asparaginase Therapy.- III. Pharmacokinetics.- The Distribution and Clearance of L-Asparaginase.- Pharmacokinetic Behavior of L-Asparaginase in Men and in Animals.- The Partitioning of L-Asparaginase between Blood and Lymph.- Critical Influence of an Enzyme-Elevating Virus upon Long-Term Remissions of Mouse Leukemia Following Asparaginase Therapy.- IV. Experimental Effects.- Experimental Studies with L-Asparaginase in Mouse Leukemias.- Experimental Investigations on Problems of the Clinical Use of L-Asparaginase.- Studies on the Glutaminase Activity of E. coli Asparaginase in Tissue Culture.- L-Asparaginase in the Treatment of Neoplastic Diseases of the Dog, Cat and Cow.- The Cytomorphological Effects of L-Asparaginase in Sensitive Cells.- Inhibitation by L-Asparaginase from E. coli of Human Malignant Melanoma Cells Growing in vitro.- Influence of L-Asparaginase Preparations of E. coli and Agouti Serum on the Homograft Reactivity in the Mouse.- Studies on the Immunosuppressive Activity of L-Asparaginase.- Experimental Immunosuppression with L-Asparaginase.- V. Animal Toxicity.- Experimental Studies on the Toxicity of Crasnitin in Animals.- VI. Resistance Problems.- The Effect of Asparaginase on Some Animal-Tumors.- Studies of Resistance to L-Asparaginase in Human Leukemia.- The Antigenicity of E.coli-Asparaginase.- Studies on Antibody Formation in Patients Treated with L-Asparaginase.- VII. Clinical Effects and Side Effects.- Treatment of Acute Leukemia with L-Asparaginase.- Clinical Experience