Fc Mediated Activity of Antibodies
Structural and Functional Diversity
(Sprache: Englisch)
This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and...
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Klappentext zu „Fc Mediated Activity of Antibodies “
This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer immunotherapy, and focuses on how IgG glycosylation regulates IgG and IgE activity in autoimmunity, allergy and infection. In closing, it presents strategies for developing novel antibody-based vaccination approaches. The book is intended for a very broad readership, including graduate students, postdocs and principal investigators with a basic grasp of immunology.Inhaltsverzeichnis zu „Fc Mediated Activity of Antibodies “
IgG Fc receptors: evolutionary considerations.- Role of FcgRs in Antibody Based Cancer Therapy.- Anti-inflammatory Activity of IgG-Fc.- IgG Fc glycosylation in human immunity.- IgE Glycosylation in Health and Disease.- Immune Complex Vaccination.- Fc receptors in anti-microbial protection.Autoren-Porträt
Jeffrey V. Ravetch Theresa and Eugene M. Lang Professor
Department Leonard Wagner Laboratory of Molecular Genetics and Immunology
Rockefeller University
1230 York Avenue, Box 98
New York, NY 10021, USA
ravetch@mail.rockefeller.edu
Falk Nimmerjahn
Professor for Immunology and Genetics
Chairman of the Institute of Genetics
Head of the Department of Biology
Department of Biology
University of Erlangen-Nuernberg
Erwin-Rommelstr. 391058 Erlangen, Germany
Bibliographische Angaben
- 2020, 1st ed. 2019, VII, 150 Seiten, 12 farbige Abbildungen, Maße: 15,6 x 23,4 cm, Kartoniert (TB), Englisch
- Herausgegeben: Jeffrey V. Ravetch, Falk Nimmerjahn
- Verlag: Springer, Berlin
- ISBN-10: 3030310558
- ISBN-13: 9783030310554
Sprache:
Englisch
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