Fluorous Parallel and Combinatorial Synthesis
(Sprache: Englisch)
This book forms a highly practical and industrially focused guide to fluorous chemistry syntheses, which are being widely explored as substitutes for traditional reactions and combinatorial methods in many companies. Written by a leading fluorous chemistry...
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Klappentext zu „Fluorous Parallel and Combinatorial Synthesis “
This book forms a highly practical and industrially focused guide to fluorous chemistry syntheses, which are being widely explored as substitutes for traditional reactions and combinatorial methods in many companies. Written by a leading fluorous chemistry research director, the book covers new solution-phase technologies, and methods that are finding application in the synthesis of small molecules, peptides, and oligosaccharides for drug discovery. The information it contains will show how fluorous methods are put to work in many contexts, such as high-throughput synthesis, proteomics, and environmentally benign solution chemistry. Special features are case studies of library syntheses using fluorous methods, as well detailed presentations of novel experimental procedures.
Inhaltsverzeichnis zu „Fluorous Parallel and Combinatorial Synthesis “
1. IntroductionHistoric overview
Fluorous compounds
Fluorous solvents
Biphasic partitions
2. Fluorous analytical and separation methods
Liquid-liquid extraction
Solid-phase extraction
Chromatography
High-throughput purification
3. Fluorous synthesis
Fluorous reaction systems
Fluorous tagging strategies
Light and heavy fluorous synthesis
Comparison with conventional solution-phase and solid-phase synthesis
4. Fluorous parallel synthesis
Fluorous catalysts
Fluorous reagents
Fluorous scavengers
Fluorous protecting groups and tags
Fluorous building blocks
5. Fluorous combinatorial synthesis
Mixture synthesis
Multi-component reactions
Microwave reactions
Solid-phase reactions
Peptide synthesis
Oligosaccharide synthesis
6. New fluorous technologies
Triphasic synthesis
Reaction and separation in supercritical CO2
Fluorous green chemistry
Autoren-Porträt von Wei Zhang
Wei Zhang received his Ph.D. degree from The University of Texas Graduate School of Biomedical Sciences. He joined the faculty of M. D. Anderson Cancer Center in 1994 where he is currently an Associate Professor and the Director of the Cancer Genomics Core Laboratory. Dr. Zhang's research programs include cancer genomics and informatics, tumor suppressor genes, and signal transduction studies. Dr. Zhang is an Associate Editor for American Association of Cancer Research journal Clinical Cancer Research, and serves on editorial board of journals Cancer Biology and Therapy, Histology and Histopathology, International Journal of Oncology, BMC Genomics, Technology in Cancer Research and Treatment, and Molecular Cancer.
Bibliographische Angaben
- Autor: Wei Zhang
- 2008, 276 Seiten, Gebunden, Englisch
- Verlag: Wiley & Sons
- ISBN-10: 0813815525
- ISBN-13: 9780813815527
Sprache:
Englisch
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