G Protein Signaling

It has been almost four decades since the discovery of signal transduction by G proteins. Much progress has been made in unraveling their roles in metabolism, cell growth, differentiation and apoptosis. G protein-coupled receptors (GPCRs) now represent a class of important therapeutic targets for drug discovery, and are involved in many different areas including CNS disorders, cardiovascular disease, inflammatory disease, tumor and metabolic disease. This collection of reviews presents the latest findings and perspectives of G protein signaling systems. The focus is placed on the discussion of the regulation and functions of various G protein subunits. New insights into interactions between G proteins and other key players of physiological processes are also put forward to inspire further studies. Researchers in the fields of neuroscience, molecular biology and pharmacology should find this publication useful as it provides an overview of the recent progress in understanding molecular mechanisms of G protein signaling.