Handbook of Complexity in Medicine

Introduction to complexity.- The mathematics of complexity.- Philosophy of complexity.- Prediction and decision making.- Information, noise... and meaning?.- "Systems" and complexity.- Small scale. Of a unifying theory in medicine.- Quantum physics and biology.- The "dark side" of our genomes: spatial organization, noise, etc.- Organization, balance between noise and information.- Networks theory and the inner life of cells.- Form and function, old paradigm true again?.- The missing mesoscales.- The magnitude of a human. What you do with what you got: of genes and the environment.- The virtual human.- The disaster of disease. A failing human.- A human ecosystem. Of identity and complexity.- Being so meta. Humans, between freedom and determinism.- Defining a human: what we eat, do, think.- Competing cultures and the righteous mind.- Stigma. Making sense as a cure and a disease.- The struggle for enlightenment. Section A The human brain 20 Cells, areas, networks, etc.- Tooling up for brain research.- Modeling the brain. Blowing a ghost in the shell.- Building, toying, and understanding.- Informing mental health. The DSM and beyond.- At the heart of a human.- Physiome project.- Multiple models of a single organ. Can we put Humpty Dumpty back together?.- Medicine and basic sciences. More than the sum of the parts.- Heart-brain connection.- A map of metabolism.- ReconX and the gps of metabolism.- Translating the models into practice.- The gaps in the map.- Clinical AI 32 Profiling and other strategies.- Infectious diseases.- Cancer therapy.- The hackers' philosophy in medical research.- Lost and found in translation.- From biological insights to clinical intelligence.- Of models and clinical pathways.- Generalizing average Joe.- Bigdata and medicine.- The resistance to adoption.- Medicine Vs Research?.- The beauty of small.- Power of one.- Tools for uncertainty.- Extending the model.- Data. Collection, quality, analyses.- eHealth as the trait d'union between research and

Marco Manca got a degree in Medicine at the University of Bologna in 2006. After years of research in Bologna, as freelancer and contractor, he became Researcher at the Maastricht University from 2009 to 2013. He is Chair of the scientific board of the European Society of Athletic Therapy and Training, and Member of the Task Force on Global Practice and Credentialing of Athletic Trainers and Therapists. He is also scientific secretary of the Grupo Luso-Italiano de Arteriosclerose, a non-profit organisation with purely scientific purposes focused on atherosclerosis and its related topics. Dr. Manca is also co-founder and President of the SCimPulse Foundation (NGO). SCimPulse aims to impulse sustainable innovation by acting as a broker of trust between otherwise far stakeholders, and by acting as a sandbox to extract meaning from the collision, sometimes serendipitous, of scientific and business actors. Since January 2014 he's been senior fellow for Medical Applications at CERN.