Handbook of Glycosyltransferases and Related Genes, m. 1 Buch, m. 1 E-Book, 4 Teile

Mannosyl (alpha-1,3[6?]-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative) (MGAT4C).- 24 Mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (MGAT2).- 25 Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B (MGAT5B).- 26 Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase (MGAT5).- 27 Mannosyl (beta-1,4-)-glycoprotein beta-1,4-N- acetylglucosaminyltransferase (MGAT3); ß1,4-N- Acetylglucosaminyltransferase III (GnT-III, GlcNAc-T III).- 28 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (GCNT2) (IGnT).- 29 O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) (OGT).- 30 Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 (POMGNT1).- 31 UDP-GlcNAc: beta-Gal beta1,3-N-acetylglucosaminyltransferase 6 (B3GNT6) (Core 3 synthase, C3GnT).- 32 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1), i-enzyme (iGnT).- 33 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2).- 34 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 (B3GNT3).- 35 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 (B3GNT5, Lc3Cer synthase).- 36 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 (B3GNT7).- 37 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 (B3GNT8).- Part 5 N-Acetylgalactosaminyltransferases.- 38 Beta-1,4 N-acetylgalactosaminyltransferase 1,2 (B4GALNT1,2).- 39 Beta1,3-N-Acetylgalactosaminyltransferase 2 (B3GALNT2).- 40 Beta1,4-N-acetylgalactosaminyltransferase-3 (B4GALNT3) and beta1,4-N-acetylgalactosaminyltransferase-4 (B4GALNT4).- 41 Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (GBGT1).- 42 Histo-blood Group A and B Transferases, Their Gene Structures, and Common O Group Gene Structures.- 43 Histo-blood Group A Variants, O Variants, and Their Alleles.- 44 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 (B3GNT4).- 45 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases (ppGalNAc-Ts).- Part 6 Fucosyltransferases.- 46 Fucosyltransferase 3. GDP-fucose lactosamine a1,3/4-fucosyltransferase. Lea and Leb histo-blood groups (FUT3, Lewis enzyme).- 47 Fucosyltransferase 4. GDP-fucose lactosamine a1,3-fucosyltransferase. Myeloid specific (FUT4).- 48 Fucosyltransferase 5. GDP-fucose lactosamine a3/4-fucosyltransferase (FUT5).- 49 Fucosyltransferase 6. GDP-fucose lactosamine a3-fucosyltransferase (FUT6).- 50 Fucosyltransferase 7. GDP-fucose lactosamine a1,3-fucosyltransferase. Sialyl-Lex specific (FUT7).- 51 Fucosyltransferase 8. GDP-fucose N-glycan core a6-fucosyltransferase (FUT8).- 52 Fucosyltransferase 9. GDP-fucose lactosamine a1,3-fucosyltransferase. Lex specific (FUT9).- 53 Fucosyltransferases 1, 2. GDP-fucose galactoside a2-fucosyltransferases. FUT1 or H blood group, FUT2 or ABH secretor status and Sec1 (FUT1, FUT2, Sec1).- 54 Fucosyltransferases 10, 11. GDP-fucose N-glycan core a1,3-fucosyltransferases (FUT10, FUT11).- 55 Fucosyltransferases 12, 13: Protein O-fucosyltransferases 1 and 2 (POFUT1, POFUT2).- Part 7 Sialyltransferases.- 56 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (ST3GAL1).- 57 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 (ST3GAL2).- 58 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 (ST3GAL3).- 59 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 (ST3GAL4).- 60 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 (ST3GAL5).- 61 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 (ST3GAL6).- 62 ST6 beta-galactoside alpha-2,6-sialyltranferase 1 (ST6GAL1).- 63 ST6 beta-galactoside alpha-2,6-sialyltranferase 2 (ST6GAL2).- 64 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (ST6GALNAC1).- 65 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (ST6GALNAC2).- 66 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 (ST6GALNAC3).- 67 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 (ST6GALNAC4).- 68 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5,6 (ST6GALNAC5,6).- 69 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (ST8SIA1).- 70 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 (ST8SIA2).- 71 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 (ST8SIA3).- 72 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 (ST8SIA4).- 73 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 (ST8SIA5).- 74 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 (ST8SIA6).- Part 8 Glucuronyltransferases.- 75 Beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P); beta-1,3-glucuronyltransferase 2 (B3GAT1,2).- 76 Beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) (B3GAT3).- Part 9 GAG polymerase and related enzymes.- 77 Chondroitin polymerizing factor, chondroitin polymerizing factor 2, chondroitin sulfate synthase 1,3 (CHPF, CHPF2, CHSY1, CHSY3).- 78 Chondroitin sulfate N-acetylgalactosaminyltransferase 1,2 (CSGALNACT1,2).- 79 Dermatan sulfate epimerases (DSE, DSEL).- 80 Exostoses (multiple)-like 1-3 (EXTL1-3).- 81 Exostosin 1,2(EXT1,2).- 82 Heparin-heparansulfate related GlcA C5-epimerase.- 83 Hyaluronan synthase 1-3 (HAS1-3).- 84 Xylosyltransferase I,II (XYLT1,2).- Part 10 Sulfotransferases.- 85 Carbohydrate sulfotransferase 10 (CHST10).- 86 Carbohydrate (chondroitin 4) sulfotransferase 11-13 (CHST11-13).- 87 Carbohydrate (chondroitin 6) sulfotransferase 3; carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 (CHST3,7).- 88 Carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 (CHST1).- 89 Carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 (CHST14).- 90 Carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 (CHST15).- 91 Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 (CHST4).- 92 Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 and 6 (CHST5,6).- 93 Carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2(CHST2).- 94 Galactose-3-O-sulfotransferase 1-4 (GAL3ST1-4).- 95 Heparan sulfate 2-O-sulfotransferase (HS2ST).- 96 Heparan sulfate (glucosamine) 3-O-sulfotransferase 1-6 (HS3ST1-6).- 97 Heparan-sulfate 6-O-sulfotransferase 1-3 (HS6ST1-3).- 98 N-Acetylgalactosamine-4-sulfotransferase-1 (GalNAc-4-ST1, CHST8) and N-Acetylgalactosamine-4-sulfotransferase-2 (GalNAc-4-ST2, CHST9).- 99 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 (NDST1).- 100 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 (NDST2).- 101 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3,4 (NDST3,4).- 102 Uronyl-2-sulfotransferase (UST).- Part 11 Glycosyltransferase-like proteins (inplicated in alpha-dystrogly).- 103 Fukutin and fukutin-related protein (FKRP).- 104 Like-glycosyltransferase; glycosyltransferase-like 1B (LARGE, GYLTL1B).- Part 12 GPI anchor biosynthesis.- 105 Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GlcNAc transferase): A complex comprised of PIGA, PIGC, PIGH, PIGQ, PIGP, PIGY and DPM2.- 106 GPI mannose extension (PIGM, PIGV, PIGB, PIGZ).- Part 13 N-Glycan precursor biosynthesis, en-bloc transfer and processing.- 107 ALG mannosyltransferases, ER lumen = alpha linkage (ALG3,9,12).- 108 Dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) (DPAGT1).- 109 Glucosidase, alpha neutral AB; glucosidase II subunit beta (GANAB, PRKCSH, a-glucosidase II).- 110 Heterodimeric Alg13/Alg14 UDP-GlcNAc transferase (ALG13,14).- 111 Mannosidase, alpha, class 1 (MAN1A1 (Golgi alpha-mannnosidase IA), Man1A2 (Golgi alpha-mannosidase IB), MAN1B1(ER alpha-mannosidase I), MAN1C1 (Golgi alpha-mannosidase IC ).- 112 Mannosidase, alpha, class 2a1 (MAN2A1, Golgi a-mannosidase II).- 113 Mannosidase, alpha, class 2a2 (MAN2A2).- 114 Mannosyl-oligosaccharide glucosidase (Glucosidase I, MOGS).- 115 N-acetylglucosamine-1-phosphate transferase, gamma subunit; N-acetylglucosamine-1- (GNPTG, GNPTAB).- 116 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (NAGPA).- 117 OST complex (OST48, Ribophorin I, Ribophorin II, DAD1).- 118 The Alg1, Alg2, and Alg11 Mannosyltransferases of the Endoplasmic Reticulum.- Part 14 Nucleotide sugar transporters.- 119 Adenosine 3'-phospho 5'-phosphosulfate transporter 1,2 (PAPST1,2) (SLC35B2,3).- 120 GDP-fucose transporter 1 (SLC35C1).- 121 Solute carrier family 35 (CMP-sialic acid transporter), member A1 (SLC35A1).- 122 Solute carrier family 35 (UDP-galactose transporter), member A2 (SLC35A2).- 123 UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter (HFRC1) (SLC35D2).- 124 UDP-xylose and UDP-N-acetylglucosamine transporter (SLC35B4).- Part 15 Transferase donor substrate biosynthesis and related reactions.- 125 Cytidine monophosphate N-acetylneuraminic acid synthetase (CMAS).- 126 Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH).- 127 Dolichyl-phosphate beta-glucosyltransferase (ALG5).- 128 Dolichyl-phosphate mannosyltransferase polypeptide (DPM1-3).- 129 Fucokinase (FUK).- 130 Fucose-1-phosphate guanylyltransferase (FPGT ).- 131 GDP-mannose pyrophosphorylase A,B (GMPPA,B).- 132 Glucosamine-6 phosphate N-acetyltransferase (GNPNAT1 / GNA1).- 133 Glutamine--fructose-6-phosphate transaminase 1,2 (GFPT1,2).- 134 Mannose phosphate isomerase (MPI).- 135 N-acetylglucosamine kinase (NAGK).- 136 N-acetylneuraminic acid phosphatase (NANP).- 137 N-acetylneuraminic acid synthase (NANS).- 138 Phosphoglucomutase 3 (= phosphoacetylglucosamine mutase) (PGM3).- 139 Phosphomannomutase 1,2 (PMM1,2).- 140 Tissue specific transplantation antigen P35B (= GDP-4-keto-6-D-deoxymannose epimerase-reductase) (TSTA3).- 141 UDP-galactose-4-epimerase (GALE).- 142 UDP-GlcNAc-2-epimerase/ManNAc kinase (GNE).- 143 UDP-glucose 6-dehydrogenase (UGDH).- 144 UDP-glucuronate decarboxylase 1 (UXS1).- 145 UDP-N-acteylglucosamine pyrophosphorylase 1 (UAP1).- BM Appendix.- Map 1: Biosynthetic Pathways of N-Glycans.- Map 2: Biosynthetic Pathways of O-Glycans.- Map 3: Biosynthetic Pathways of Glycosphingolipids.- Map 4: Biosynthetic Pathways of Proteoglycans.- Map 5: Biosynthetic Pathways of GPI-Anchor.</p>

began his research at the Cancer Institute of the Hokkaido University Medical School in 1984 he has been studying the metabolism and function of glycolipids as well as glycoproteins. He worked at the Osaka Medical Center for Maternal and Child Health as chief researcher from 1995 to 1999 and in the Department of Biochemistry, Osaka University Medical School, as associate professor from 1999 to 2003. He was then promoted to full professor at the Kochi University Medical School in 2003. His major contribution has been purification, molecular cloning, and gene targeting of a glycan sulfotransferase responsible for the biosynthesis of sulfatides and discovery of the Gal 3-O-sulfotransferase gene family. His research focus now has shifted to the biogenesis of membrane microdomains with the establishment of a novel labeling method called EMARS for identification of cell surface molecular clustering in living cells.



Minoru Fukuda is a professor at the Sanford-Burnham Medical Research Institute in La Jolla, California, and an adjunct professor in the Department of Pathology at the University of California, San Diego. Dr. Fukuda earned his Ph.D. in biochemistry from the University of Tokyo in 1973 and completed post-doctoral research training at the Yale University School of Medicine. He was an assistant professor at the University of Washington and the Fred Hutchinson Cancer Research Center in Seattle, Washington, working with Dr. Senichiro Hakomori, before he was recruited to the Burnham Institute as director of the glycobiology program in 1984. In 1994-1995, Dr. Fukuda was also the biochemistry chair of the Institute of Medical Science, the University of Tokyo. Dr. Fukuda has published more than 280 original scientific papers, authored and edited many books, and served as executive editor and associate editor for Biochimica et Biophysica Acta (BBA) and Cancer Research, respectively. Dr. Fukuda received the Karl Meyer Award given by the Society for Glycobiology, The Mizutani Award, MERIT Award and Program Project Grant, and recently, the Alliance of Glycobiologists for Detection of Cancer from the National Cancer Institute, National Institutes of Health (NIH). His research focus is on the structure, biosynthesis, and function of glycoproteins. He is particularly interested in the tumor suppresser function of carbohydrates and heparan sulfate for cellular signals in cell-cell interaction.



Hisashi Narimatsu is a founder and the director of the Research Center of Medical Glycoscience (RCMG), a part of the National Institute of Advanced Industrial Science and Technology (AIST) in Japan, and is energetically leading comprehensive activities in glycoscience. He graduated from the School of Medicine and the Graduate School of Medicine at Keio University, where he received his M.D. and Ph.D., respectively. He successfully cloned the first glycosyltransferase, 1,4-galactosyltransferase, during his postdoc at the U.S. National Institutes of Health (NIH), and thereafter he has continued to devote his scientific career to finding and cloning many new glycosyltransferases. In 2000, he joined AIST and since then has been leading three national projects, i.e., the Glycogene Project, the Structural Glycomics Project, and the Medical Glycomics Project, to facilitate the progress of glycoscience.

 

Yoshiki Yamaguchi received his Ph.D. in 1998 at the Graduate School of Pharmaceutical Sciences, the University of Tokyo (under Professors Ichio Shimada and Yoji Arata). He continued his research as a postdoctoral research fellow and then as a research associate in the same group. From 2001 to 2007, he was a lecturer at Nagoya City University (under Professor Koichi Kato) and then moved to his current position at RIKEN, the Systems Glycobiology Research Group, as a team leader of the Structural Glycobiology Team. His current study focuses on structural analyses of glycoproteins and glycan-related proteins. He has been holding posts concurrently at Nagoya City University (from 2007) and at Tokyo Medical and Dental University (from 2008) as a visiting professor. He received Young Scientist Awards from GlycoTOKYO in 2006 and from the Japanese Society of Carbohydrate Research in 2007.



Takashi Angata received a Ph.D. degree in biochemistry from the Graduate School of Science, the University of Tokyo, in 1998. He has served as post-doctoral fellow to Professor Ajit Varki at the University of California, San Diego (1998-2003), research scientist at the National Institute of Advanced Industrial Science and Technology (AIST) in Japan (2003-2009), specially appointed associate professor at Osaka University (2009-2011), and now as team leader at the RIKEN Advanced Science Institute (2011-present).

Dr. Angata was a major contributor in the expansion of the Siglec family of sialic acid recognition proteins and made several seminal discoveries in the field, such as the concerted evolution of activating and inhibitory Siglecs as paired receptors. His current research is focused on the role of activating Siglecs in innate immunity and chronic diseases.