Heart Function in Health and Disease

A. The Developing Heart.- 1. Heart story: A view to the past.- 2. Postnatal growth and restructuring of mammalian hearts.- 3. Ontogenetic development of cardiac inotropic responsiveness.- B. Regulation of Cardiac Channels.- 4. Activation mechanisms of cardiac muscarinic K channels.- 5. Multiple cyclic GMP binding proteins involved in the regulation of cardiac calcium channels.- 6. Participation of the Na+-H+ exchange pathway in cardiac pathology.- 7. Phospholipase D: A new avenue to the phospholipid signalling pathways in the myocardium.- C. Cardiac Electric Field.- 8. Cardiac pacemaker activity: From single cells to modelling the heart.- 9. Physiology of the cardiac electric field.- 10. Modelling of the cardiac electrical field.- 11. The temporal behaviour of the cardiac electric field.- 12. Computer modelling of cardiac arrhythmias.- D. Heart in Chronic Hypoxia.- 13. Relationship between heart mass and hemoglobin/hematocrit at high altitude - Function or fallacy.- 14. Functional assessment of the hypertrophic right ventricle in the rat heart.- 15. Chronic hypoxia-induced right ventricular enlargement: Age-dependent changes of collagenous and non-collagenous cardiac protein fractions.- 16. Sarcolemnal cation transport systems in rat hearts acclimatized to high altitude hypoxia, influence of 7-oxo-prostacyclin.- 17. Effects on the heart of two forms of chronic hypoxia.- E. Cardiac Hypertrophy and Failure.- 18. Thyroid hormones and cardiac hypertrophy.- 19. Diastolic dysfunction of the heart. Pharmacological strategies for modulating calcium sequestration of the sarcoplasmic reticulum.- 20. Conduit coronary artery structure and function.- 21. Heart failure: A disease of adaptation.- 22. Involvement of sarcolemnal Na+-K+ ATPase in the pathogenesis of heart disease.- 23. Neuroendocrine response to heart failure.- 24. Alterations of extracellular matrix in cardiac atrophy.