High Throughput Screening for Novel Anti-Inflammatories
(Sprache: Englisch)
Combinatorial chemistry in conjunction with High Throughput Screening
(HTS) is revolutionizing the drug discovery process. Yet, we have much
to learn about the integration of these powerful techniques with
information from genomics, proteomics,...
(HTS) is revolutionizing the drug discovery process. Yet, we have much
to learn about the integration of these powerful techniques with
information from genomics, proteomics,...
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Klappentext zu „High Throughput Screening for Novel Anti-Inflammatories “
Combinatorial chemistry in conjunction with High Throughput Screening (HTS) is revolutionizing the drug discovery process. Yet, we have much
to learn about the integration of these powerful techniques with
information from genomics, proteomics, computation and pharmacokinetics
before dramatic increases in the drug discovery/development processes
can be achieved. The chapters in this book represent the state of the
art regarding the integration of combinatorial chemistry and HTS in
connection with anti-inflammatory targets. Obviously, there is much work
to be done beyond what is described in this text, nevertheless, it
should set the stage for creative thinking among scientists of many
disciplines for the accomplishment of our ultimate goals in treating
inflammatory diseases.
Inhaltsverzeichnis zu „High Throughput Screening for Novel Anti-Inflammatories “
- List of Contributors- Intoduction
- Sharon M. Dankwardt: Solid phase synthesis: applications to combinatorial libraries
- Mohamed A. Iqbal and Mark A. Ator: Proteaspme inhibitors
- Tariq Ghayur, Sheryl J. Hays and Robert V. Talanian: Caspase-1 (ICE) and other caspases as drug discovery targets: opportunities and progress
- William A. Metz and Norton P. Peet: Elastase inhibitors
- M. Anthony Leesnitzer, D. Mark Bickett, Marcia L. Moss and J. David Becherer: A high-throughput assay for the TNF conerting enzyme
- Kenneth D. Rice and William R. Moore: Tryptase inhibitors
- Falguni Dasgupta: Selectin antagonists
- Kerry W. Fowler and David T. Crowe: Cell adhesion integrins as pharmaceutical targets
- Brion W. Murray, Yoshitaka Satoh and Bernd Stein: Inhibitors of the MAPK pathway
- Mark J. Suto and Anthony M. Manning: Inhibition of NF-kB. Terry L. Bowlin, Stephen D. Yanofsky and Herman Schreuder: IL-1 antagonist discovery
- Mark A. Giembycz: Phosphodiesterase inhibitors for respiratory disease
- Subject index
Bibliographische Angaben
- 2000, 258 Seiten, Maße: 16 x 24,1 cm, Gebunden, Englisch
- Herausgegeben von Kahn, Michael
- Herausgegeben: Michael Kahn
- Verlag: Springer
- ISBN-10: 3764359129
- ISBN-13: 9783764359126
- Erscheinungsdatum: 01.05.2000
Sprache:
Englisch
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