Hormonal Carcinogenesis III

Estrogen and c-myc Protooncogene Actions in Human Breast Cancer.- 18 Steroid Hormone Regulation of Vascular Endothelial Growth Factor (VEGF) Production: A Potential Step in Hormonal Carcinogenesis.- 19 TGF-?/Estrogen-inducible Early Gene (TIEG): A Candidate Tumor Suppressor or Cell Cycle Regulator?.- 7. Aromatase: Implications For Breast Cancer.- Aromatase: Implications for Breast Cancer.- 20 Control of Estrogen Biosynthesis in Breast Cancer.- 21 Regulation of Aromatase in Normal and Malignant Breast Tissues: The Role of the Immune System.- 22 Regulation of Aromatase in Breast Cancer and Correlation of Aromatase and Cyclooxygenase Gene Expression.- 8. Organ Site: Prostate/Ovary.- Androgen Receptor and its Role in the Development and Control of Androgen-independent Prostate Cancer.- 23 Etiologic Mechanisms in Epithelial Ovarian Cancer.- 24 Stromal Influences in Prostatic Carcinogenesis.- 25 Androgen Receptor Structure and Function in Prostate Cancer.- 9. Osteoporosis and Estrogens.- Hormone Replacement Therapy: A Clinical Overview.- 26 Role of Estrogen and Bone Morphogentic Protein Signaling in Osteoblast Differentiation.- 27 Estrogens and the Skeleton.- 10. Cardiovascular Disease and Estrogens/Progestins.- 28 Mechanisms of Estrogen Action on the Cardiovascular System.- 29 Atherosclerosis and Hormone Replacement Therapy: The Role of Estrogen in Secondary Prevention of Cardiovascular Events.- Viewpoint.- 30 Long-term Hormone Replacement Therapy: A Contrary Point of View.- Epilogue.- 31 A Unified General Mechanism for Hormonal Carcinogenesis Begins to Emerge.- Communications.- Session I. Epidemiology/Human Studies.- The Risk of Postmenopausal Breast Cancer After Estrogen and Estrogen-Progestin Replacement.- No Significant Difference in Age at Menarche, Menstrual Cycle Length, Age at First Full Term Pregnancy, and Nulliparity among BRCA1 Mutation Carriers Compared with Their Unaffected Relatives.- Cell Proliferation and Apoptosis in the Normal Breast Epithelium of Pre, Peri, and Postmenopausal Women.- Expression and Estrogen Inducible Promoter Activity of Human Estrogen-responsive Finger Protein Gene in Breast and Ovarian Cancer Cells.- Novel Small Molecule IL-6 Inhibitors as Anti-Cancer Drugs.- Session II. Metabolism Studies/Cellular & Molecular Biology.- Cellular Transforming Activity and Genotoxic Effects of 17?-EstradioI and Its Eight Metabolites in Syrian Hamster Embryo Cells.- Evidence for an Initiation Mechanism of 17? Estradiol Carcinogenesis.- Estradiol Metabolism by Rat Liver Microsomes from Strains Differing in Susceptibility to Mammary Carcinogenesis.- Induction of Breast Cancer in Noble Rats with a Combination of Estrogen and Testosterone.- Isolation and Purification of Breast Carcinoma Cell Lines from a Noble Rat.- The ACI Rat as a Genetically Defined Animal Model for the Study of Estrogen Induced Mammary Cancers.- Characteristics of Dehydroepiandrosterone-induced Hepatocarcinogenesis in the Rat.- Hepatic Toxicity of Estrogen in Armenian and Chinese Hamsters.- Suppression of Liver Tumor Formation by the Liver Microenvironment of Female, but Not Male, Syngeneic Hosts.- Dietary Energy Restriction Inhibits Estrogen Induced Pituitary Tumorigenesis in a Rat Strain Specific Manner.- Estrogen-induced Prolactinoma Development: A Role for Cell-Cell Communication.- Combined Administration of Transplacental Ethylnitrosourea and Postnatal Diethylstilbestrol Induce Neural Differentiation in Interstitial Cells of the Golden Hamster Kidney.- Aromatase Overexpression: Is Aromatase an Oncogene?.- Genetic Toxicity In Vitro of Bisphenol A-Diglycidylether (BADGE) and its Hydrolysis Products.- Lack of Genotoxicity of Major Mammalian and Plant Lignans at Various Endpoints In Vitro.