Human Evolutionary Genetics

Section 1: Introduction 1. Why Study Human Evolutionary Genetics? Section 2: How do we study Genome Diversity? 2. Structure, Function and Inheritance of the Human Genome 3. The Diversity of the Human Genome 4. Discovering and Assaying Genome Diversity Section 3: How do we Interpret Genetic Variation? 5. Processes Shaping Diversity 6. Making Inferences from Diversity Section 4: Where and When did Humans Originate? 7. Human Apes 8. Origins of Modern Humans Section 5: How did Humans Colonize the World? 9. The Distribution of Diversity - Out of Africa and into Asia, Australia and Europe 10. Agricultural Expansions 11. Into New Found Lands 12. What Happens When Populations Meet? Section 6: What use is an Evolutionary Perspective? 13. Understanding the Past and Future of Phenotypic Variation 14. Health Implications of Our Evolutionary Heritage 15. Identity and Identification

Mark Jobling earned a degree in Biochemistry and a DPhil at the University of Oxford, UK, and in 1992 came to the University of Leicester, UK, where he is now a Wellcome Trust Senior Fellow in Basic Biomedical Sciences and Reader in Genetics. Mark's interests are in Y chromosome diversity as a tool for addressing questions in human evolution, genealogy and forensics, and also male infertility and haploid mutation processes. Matthew Hurles earned his degree in biochemistry at Oxford University, UK, and PhD in Leicester, UK. He was until recently a Research Fellow at the McDonald Institute for Archaeological Research at Cambridge University, UK, analyzing genetic variation with the aim of improving our understanding of the human past. He is now at the Wellcome Trust Sanger Institute near Cambridge, UK, investigating the unusual evolutionary dynamics of recently duplicated genomic regions. Chris Tyler-Smith earned his degree in biochemistry at Oxford University, UK, and PhD in Edinburgh, UK. For the last few years he has been a University Research Lecturer in the Biochemistry Department at Oxford, UK, working on the structure and function of human centromeres, and the application of Y-chromosomal DNA variation to the understanding of the human past. He is now at the Wellcome Trust Sanger Institute near Cambridge, UK, studying the genetic changes that have taken place during recent human evolution.

"I strongly recommend this book to anyone with an interest in human evolutionary genetics or anthropological genetics. It would be an ideal choice for advanced undergraduates and graduate courses on this topic, and would also be a key reference for those active in such research." - Human Genomics "This is an absolutely superb book! I have been recommending it enthusiastically to professional colleagues, graduate students, and even the occasional highly motivated undergraduate student, and the response has been overwhelmingly positive. Not only is the book unique in terms of topical coverage, but it is also extremely well executed. In fact, it is one of the best textbooks on any subject I have ever read. It belongs on the shelves of everyone interested in the genetic aspects of human evolution. There is also much of value in it for paleoanthropologists, historical linguistics, archaeologists, and human biologists (biological anthropologists), as well as for geneticists with various complementary specialties and interests." - American Journal of Human Genetics "I strongly recommend Human Evolutionary Genetics as an undergraduate textbook. At the same time, I recommend this book to any readers with an interest in human evolution or human genetics." - Human Genetics