HYPNOTIC, ANALGESIC, AND EEG ENDPOINTSDURING INTRAVENOUS ANAESTHESIA; .
Effective doses, catecholamine, and cardiovascular responses
(Sprache: Englisch)
In this study, differences, effective doses, and concentrations of propofol and thiopental in hypnotic, analgesic, and EEG end-point were evaluated. Nine rabbits, and 143 patients were studied. In rabbits propofol revealed to be the best choice because...
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In this study, differences, effective doses, and concentrations of propofol and thiopental in hypnotic, analgesic, and EEG end-point were evaluated. Nine rabbits, and 143 patients were studied. In rabbits propofol revealed to be the best choice because recovery was rapid and breathing patterns were well preserved. In humans propofol attenuated better the catecholamine response (CA) to tracheal intubation (TI) than thiopental. The CA response to TI was almost totally blocked during burst suppression pattern (BSP) of EEG induced by propofol. At BSP level thiopental attenuated the cardiovascular response to TI nearly as well as propofol. Remifentanil infusion started before propofol significantly reduced times and doses of propofol at the attainment of differrent endpoints. Remifentanil also affects the BIS value and might be kinetically useful for loss of consciousness because it accelerates the hypnotic onset of propofol. Propofol and thiopental have similarities in BSP but duringpropofol 13-15 Hz spindle oscillations are seen. An algorithm for automatic detection of BSP was developed.
Autoren-Porträt von Seppo Mustola
Mustola SeppoI received the M.D. degree in 1983, the Specialist degree in anesthesiology in 1991, and the Ph.D. degree in 2004. I work as a Staff Anesthesiologist and a Chief of the Pain Clinic in the South Karelia Central Hospital, Finland. My research has focused on intravenous anesthetics and their effects on EEG; 16 scientific articles.
Bibliographische Angaben
- Autor: Seppo Mustola
- 2008, 100 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Verlag: VDM Verlag Dr. Müller e.K.
- ISBN-10: 3639087534
- ISBN-13: 9783639087536
Sprache:
Englisch
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