Hypoglycemic and Hypolipidemic Effect Dillenia indica Fruit and Bark

Dillenia indica Linn, commonly known as Chalta, is abundantly available almost all over Bangladesh. The present study was carried out to evaluate the anti-diabetic and anti-hyperlipidemic properties of Dillenia indica on type 2 diabetic model rats. A single intraperitoneal (i.p) dose of chloroform fraction (200 mg/ kg body weight) of methanol extract of Dillenia indica fruit significantly reduced fasting blood glucose (FBG) level on alloxan induced diabetic rats. The most significant reduction of FBG level (65%) after 50 hour of administration. This effect almost similar to that of standard drug metformin (150 mg/kg b.w.). In alloxan induced diabetic rat, the total cholesterol and serum triglyceride levels were increased by 49 and 41%, respectively. Chloroform fraction of fruit also reduced the total cholesterol and serum triglyceride level 60 and 55%, respectively on alloxan induced rat. On the hand, CHCl3 fraction of D. indica bark at early phase reduced the blood glucose leveland and later at 50 hour it increased to 30%, meanwhile increased 28 and 54% of TC and TG level, respectively on alloxan induced rat.