IGF and Nutrition in Health and Disease
(Sprache: Englisch)
From birth to death, the insulin-like growth factors (IGF) -a system of proteins, binding proteins, and cell receptors that are widely expressed in all tissues-plays critical roles in metabolism, normal growth and development, and numerous acute and chronic...
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From birth to death, the insulin-like growth factors (IGF) -a system of proteins, binding proteins, and cell receptors that are widely expressed in all tissues-plays critical roles in metabolism, normal growth and development, and numerous acute and chronic diseases. The IGF system is fundamentally related to growth hormone and insulin, but also nutritional state. In IGF and Nutrition in Health and Disease, leading researchers and physicians from diverse disciplines comprehensively review for the first time how specific nutrients or adverse nutritional states impact gene expression, circulating concentrations, and bioactivity of the IGF proteins. The authors describe the fundamentals of the IGF system, explain its basic mechanisms of action, and examine the interactions between IGF and nutritional status from the molecular to the population levels. Their discussion of the essential interrelationships between IGF and nutrition, including specific nutrients, in physical developmentacross the life span illuminates the balance between normal growth and development and abnormal cellular growth resulting in tumor formation. They also fully examine the clinical aspects of nutrition and IGF, from pre- and postnatal development through old age, in the maintenance of normal metabolism, bone and muscle health, and their role in pathological states. Special attention is given to critical illness, diabetes, gastrointestinal diseases, kidney failure, endocrine dysfunctions, cardiovascular disease, neurological disorders, and cancer, as well as to their potential for IGF therapy. Comprehensive and authoritative, IGF and Nutrition in Health and Disease is a benchmark review of nutrition and the IGF system in human health and disease, providing a clear understanding of the critical importance of the IGF system and nutritional state to human growth, metabolism, disease development, and therapy.
Inhaltsverzeichnis zu „IGF and Nutrition in Health and Disease “
I . OverviewOverview and Molecular Aspects of the Insulin-Like Growth Factor System
Martin L. Adamo, Lai Wang, Lisa Heron, Dalit Ben-Yosef, Hong Zhao, and Derek Le Roith
II. IGF and Nutritional Status
Regulation of Insulin-Like Growth Factor-I by Nutrition
Jean-Paul Thissen, Véronique Beauloye, Jean-Marie Ketelslegers, and Louis E. Underwood
Nutrition and IGF Proteins in Chronic Malnutrition and Critical Illness
Pei-Ra Ling and Bruce R. Bistrian
The Insulin-Like Growth Factors and Assessment of Nutritional Status
M. Sue Houston
III. Growth and Development
Regulation of Growth and the Insulin Growth Factor System by Zinc
Ruth S. MacDonald
The Role of the Insulin-Like Growth Factor System in Pre- and Postnatal Growth, Development, and Tumorigenesis
Charles T. Roberts, Jr.
The Insulin-Like Growth Factor Axis in the Fetus and Neonate
Cynthia L. Blanco and Robert J. Ferry, Jr.
Nutrition and the IGF System in Reproduction
Frank A. Simmen, Inseok Kwak, Jason L. Blum, and Rosalia C. M. Simmen
The Insulin Growth Factor System and Nutrition in Adulthood and Aging
Moira S. Lewitt and Kerstin Hall
IV. IGF and Organ Systems
Nutrition and Insulin Growth Factor-I in Relation to Bone Health and Disease
Jean-Philippe Bonjour, Patrick Ammann, Thierry Chevalley, and René Rizzoli
Effect of Insulin-Like Growth Factor Proteins on Skeletal Muscle Protein Metabolism During Normal and Catabolic Conditions
Charles H. Lang and Robert A. Frost
Insulin-Like Growth Factors and Nervous System Disorders
Gary Meyer, Aparna Bole, and Eva L. Feldman
The Kidney and the Insulin-Like Growth Factor System in Health and Disease
Ralph Rabkin, Steven S. Guest, and Franz Schaefer
V. IGF in Disease States
The IGF and IGFBP System in InsulinResistance and Diabetes Mellitus
Kerstin Brismar and Moira S. Lewitt
Insulin-Like Growth Factors in Relation to Gastrointestinal Diseases and Parenteral Nutrition
Denise M. Ney
Impact of Critical
... mehr
Illness on the Growth Hormone/Insulin Growth Factor System in Relation to Other Endocrine Responses
Greta Van den Berghe
Mechanisms of Cardiac Hypertrophy and the Development of Heart Failure: Role of Insulin-Like Growth Factor-I and Angiotensin-II
Patrice Delafontaine, Marijke Brink, and Yao-Hua Song
Roles of the Insulin-Like Growth Factor System and Nutrition in Cancer
Claire M. Perks and Jeffrey M. P. Holly
Appendix A
Appendix B
Index
Greta Van den Berghe
Mechanisms of Cardiac Hypertrophy and the Development of Heart Failure: Role of Insulin-Like Growth Factor-I and Angiotensin-II
Patrice Delafontaine, Marijke Brink, and Yao-Hua Song
Roles of the Insulin-Like Growth Factor System and Nutrition in Cancer
Claire M. Perks and Jeffrey M. P. Holly
Appendix A
Appendix B
Index
... weniger
Bibliographische Angaben
- 2004, 359 Seiten, Maße: 25,4 cm, Gebunden, Englisch
- Herausgegeben:Houston, M. Sue; Holly, Jeffrey M. P.; Feldman, Eva L.
- Verlag: Humana Press
- ISBN-10: 1588291901
- ISBN-13: 9781588291905
Sprache:
Englisch
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