Immunotoxicity of Metals and Immunotoxicology

Immunotoxicity of metals and immunotoxicology.- The Immune System and Immunotoxicology.- The immune system: an integrated overview.- Concepts and definitions in immunotoxicology.- Immunogenetics.- Dose-effects and dose-responses in immunotoxicology: problems and conceptual considerations.- Recognition of metals by proteins.- Hypersensitivity.- Hypersensitivity: clinical aspects.- Animal models for predicting hypersensitivity reactions to small molecules.- Contact allergy to chromium and nickel.- Allergenic potential of platinum compounds.- Autoimmunity.- Role of cytokines in the induction of autoimmunity.- Immunologically mediated manifestations of metals.- Tests for predicting sensitization to chemicals and their metabolites, with special reference to heavy metals.- Immunotoxicity of Metals.- Immunological and immune-mediated toxic effects of gold compounds used in the treatment of rheumatoid arthritis.- Toxicology of inorganic mercury.- Immunotoxicology of cobalt and selenium.-Immunological diagnosis of chronic beryllium disease in humans and animals.- Effect of organotin compounds on lymphoid organs and lymphoid functions: an overview.- Immunotoxicity of lead, cadmium and arsenic: experimental data and their relevance to man.- Immunotoxicology of lead.- Adverse effects of zinc on the immune system.- Investigations of Immunotoxicity.- Immunotoxicology: functional changes.- The immune system as a target for toxicity: a tiered approach to testing, with special emphasis on histopathology.- Investigative methods: classical techniques.- Reduced immunocompetence and relationships to histopathology of the lymphoid system.- The Immune System: Human Studies.- Clinical aspects of potential innnunotoxic effects of chemicals: diagnosis and epidemiological caution.- Long-term monitoring of human populations for effects on components of the immune system.- Relevance of atopy to the immunotoxic effects of metals.- List of participants.