Inhibition of Angiogenesis by Potential Chemopreventive Agents
Establishment of a Human In vitro Anti-Angiogenesis Assay and Mechanistic Evaluation of Potent Inhibitors
(Sprache: Englisch)
A new human in vitro anti-angiogenesis assay was established and applied to identify novel angiopreventive agents. Subsequently, two chemopreventive compounds, xanthohumol (XN) from Humuluslupulus L. (hop) and sulforaphane (SFN), an isothiocyanate derived...
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A new human in vitro anti-angiogenesis assay was established and applied to identify novel angiopreventive agents. Subsequently, two chemopreventive compounds, xanthohumol (XN) from Humuluslupulus L. (hop) and sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables (Brassicaceae), were selected for detailed investigation of their angiopreventive potential and mechanisms involved in the inhibition of angiogenesis. Representative targets included effects at the transcriptional levels of pro-angiogenic factors, anti-gelatinolytic and anti-endothelial activity. In vivo, XN was shown to exhibit astrong anti-tumour potency on human breast cancer xenograftsmediated by the inhibition of tumour-induced angiogenesis. These findings strongly suggest that XN and SFN represent attractive chemopreventive lead structures possessing a remarkable potentialto prevent tumour development.
Autoren-Porträt von Elisabeth Klenke
Elisabeth Klenke, Ph.D.: Toxicology, German Cancer Research Center, Heidelberg, Germany. European Registered Toxicologist and Preclinical Reviewer Swissmedic, Switzerland.
Bibliographische Angaben
- Autor: Elisabeth Klenke
- 132 Seiten, Maße: 15 x 22 cm, Kartoniert (TB), Englisch
- Verlag: VDM Verlag Dr. Müller
- ISBN-10: 3639036301
- ISBN-13: 9783639036305
- Erscheinungsdatum: 07.12.2013
Sprache:
Englisch
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