Insilico Binding Studies of Phenolic Compounds With Tyrosinase
Vitiligo Is an Acquired Cutaneous Skin Disease Characterized By Declining Melanocyte Function and Depigmentation
(Sprache: Englisch)
Copper containing tyrosinase enzyme is responsible for melanin biosynthesis in human. Anomalous growth of this enzyme causes hyper-pigmentation related disorders. Monophenols and Diphenols compounds are used as inhibitors and among these the some compounds...
Leider schon ausverkauft
versandkostenfrei
Buch
49.90 €
Produktdetails
Produktinformationen zu „Insilico Binding Studies of Phenolic Compounds With Tyrosinase “
Klappentext zu „Insilico Binding Studies of Phenolic Compounds With Tyrosinase “
Copper containing tyrosinase enzyme is responsible for melanin biosynthesis in human. Anomalous growth of this enzyme causes hyper-pigmentation related disorders. Monophenols and Diphenols compounds are used as inhibitors and among these the some compounds exhibited significant inhibitory activities against the tyrosinase. Molecular docking studies of these enzymes with those metabolites have been the focus of this study. The active site of the tyrosinase is the two copper ions as binding site. The metal ions seem to play an important role in establishing the interaction within the cavity of active sites. Discovery Studio3.1 was utilized to investigate the conformation and binding affinities of our small molecules. The results indicate a possible mechanism for their anti-tyrosinase activity which may involve anability to chelate the copper atoms which are required for the catalytic activity of tyrosinase.
Autoren-Porträt von Upendra Bhele
Bhele, UpendraAs a Bioinformatics postgraduate (MSc, MTech) Upendra Bhele has worked on various projects as chemoinformatics, pharmacoinformatics and docking studies. He has various research papers under his name
Bibliographische Angaben
- Autor: Upendra Bhele
- 2013, 96 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Verlag: LAP Lambert Academic Publishing
- ISBN-10: 3659463744
- ISBN-13: 9783659463747
Sprache:
Englisch
Kommentar zu "Insilico Binding Studies of Phenolic Compounds With Tyrosinase"
0 Gebrauchte Artikel zu „Insilico Binding Studies of Phenolic Compounds With Tyrosinase“
Zustand | Preis | Porto | Zahlung | Verkäufer | Rating |
---|
Schreiben Sie einen Kommentar zu "Insilico Binding Studies of Phenolic Compounds With Tyrosinase".
Kommentar verfassen