Intracellular Delivery
(Sprache: Englisch)
This book features a special subsection of Nanomedicine, an application of nanotechnology to achieve breakthroughs in healthcare. It exploits the improved and often novel physical, chemical and biological properties of materials only existent at the...
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This book features a special subsection of Nanomedicine, an application of nanotechnology to achieve breakthroughs in healthcare. It exploits the improved and often novel physical, chemical and biological properties of materials only existent at the nanometer scale. As a consequence of small scale, nanosystems in most cases are efficiently uptaken by cells and appear to act at the intracellular level. Nanotechnology has the potential to improve diagnosis, treatment and follow-up of diseases, and includes targeted drug delivery and regenerative medicine; it creates new tools and methods that impact significantly existing conservative practices.
Klappentext zu „Intracellular Delivery “
During the last decade, intracellular drug delivery has become an emerging area of research in the medical and pharmaceutical field. Many therapeutic agents can be delivered to a particular compartment of a cell to achieve better activity. It is very prolific field as it appears that the pace of discovery of intracellular drugs (to cellular or organ compartments) is proceeding faster than conventional ones. The lipidic nature of biological membranes is the major obstacle to the intracellular delivery of macromolecular and ionic drugs. Additionally, after endocytosis, the lysosome, the major degradation compartment, needs to be avoided for better activity. Various carriers have been investigated for efficient intracellular delivery, either by direct entry to cytoplasm or by escaping the endosomal compartment. These include cell penetrating peptides, and carrier systems such as liposomes, cationic lipids and polymers, polymeric nanoparticles, etc. Various properties of these carriers, including size, surface charge, composition and the presence of cell specific ligands, alter their efficacy and specificity towards particular cells. This book summarizes various aspects of targeted intracellular delivery of therapeutics including pathways, mechanisms, and approaches. Several case studies featuring a high success on an industrial scale are reviewed.
Autoren-Porträt
Dr Ales Prokop is a retired Professor of Chemical Engineering (Vanderbilt University, Nashville, USA). Throughout his long and varied career he has always worked at the boundary between biology, medicine and engineering and has gained a unique insight into the many disciplines required to discover and develop effective therapies. Having taken a first degree in engineering (MSc, Prague) he gained a doctorate in Microbiology (PhD, Prague) and then a further degree in Biology (DSc, Prague). Throughout his career he has concentrated on biotechnology and bioengineering and has gained considerable expertise in the vital links between those two areas. The systems approach has been a leading theme of his scientific work and he has been able to apply the knowledge gained to the commercial arena. Latterly, he has worked in the area of bioartificial organs, drug delivery and systems biology. He is the author of over 160 publications and reviews in scientific journals and books and he has organized several international meetings and symposia. He has always felt it vitally important to transfer his scientific research, knowledge and results into practice and has collaborated with many companies and scientists in the pharmaceutical arena in both research and teaching.t into the many disciplines required to discover and develop effective therapies. Having taken a first degree in engineering (MSc, Prague) he gained a doctorate in Microbiology (PhD, Prague) and then a further degree in Biology (DSc, Prague). Throughout his career he has concentrated on biotechnology and bioengineering and has gained considerable expertise in the vital links between those two areas. The systems approach has been a leading theme of his scientific work and he has been able to apply the knowledge gained to the commercial arena. Latterly, he has worked in the area of bioartificial organs, drug delivery and systems biology. He is the author of over 160 publications and reviews in scientific journals and
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books and he has organized several international
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Bibliographische Angaben
- 2011, 10 Seiten, 10 farbige Abbildungen, Maße: 23,5 cm, Gebunden, Englisch
- Herausgegeben von Prokop, Ale
- Verlag: Springer Netherlands
- ISBN-10: 9400720505
- ISBN-13: 9789400720503
Sprache:
Englisch
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