Introduction to Genetic Analysis, International Edition
(Sprache: Englisch)
This best-selling textbook, known for its prominent authorship, exposes students to the landmark experiments in genetics, teaching them how to analyze experimental data and draw their own conclusions based on scientific thinking.
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Klappentext zu „Introduction to Genetic Analysis, International Edition “
This best-selling textbook, known for its prominent authorship, exposes students to the landmark experiments in genetics, teaching them how to analyze experimental data and draw their own conclusions based on scientific thinking. The 10th edition has been updated with key advances in genetics and cutting-edge experiments and techniques. New co-author John Doebley, a highly respected population geneticist, brings a fresh, student-driven perspective to completely new chapters on Population and Quantitative Genetics. The key chapters on Evolutionary Genetics and The Evolution of Genes and Traits have been heavily revised to reflect recent discoveries in these areas. The end-of-chapter problems have also been revised and updated, giving students great new exercises to test their understanding.
The book is supported by a companion website (A href="which provides online quizzing with feedback and 45 FLASH Animations on core concepts or processes in Genetics.
Inhaltsverzeichnis zu „Introduction to Genetic Analysis, International Edition “
From the Contents:The Genetics Revolution in the Life Sciences
The nature of biological information
How information becomes biological form
Genetics and evolution
Genetics has provided a powerful new approach to biological research
Model organisms have been crucial in the genetics revolution
Genetics changes society
Genetics and the future
PART I: TRANSMISSION GENETICS
Single-Gene Inheritance
Single-gene inheritance patterns
The chromosomal basis of single-gene inheritance patterns
The molecular basis of Mendelian inheritance patterns
Some genes discovered by observing segregation ratios
Sex-linked single-gene inheritance patterns
Human pedigree analysis
Independent Assortment of Genes
Mendel's law of independent assortment
Working with independent assortment
The chromosomal basis of independent assortment
Polygenic inheritance
Organelle genes: inheritance independent of the nucleus
Mapping Eukaryote Chromosomes by Recombination
Diagnostics of linkage
Mapping by recombinant frequency
Mapping with molecular markers
Centromere mapping with linear tetrads
Using the chi-square test for testing linkage analysis
Accounting for unseen multiple crossovers
Using recombination-based maps in conjunction with physical maps
The molecular mechanism of crossing over
The Genetics of Bacteria and Their Viruses
Working with microorganisms
Bacterial conjugation
Bacterial transformation
Bacteriophage genetics
Transduction
Physical maps and linkage maps compared
Gene Interaction
Interactions between the alleles of a single gene: variations on dominance
Interaction of genes in pathways
Inferring gene interactions
Penetrance and expressivity
PART II: FROM DNA TO PHENOTYPE
DNA: Structure and Replication
DNA: the genetic material
The DNA structure
Semiconservative replication
Overview of DNA replication
The replisome: a remarkable replication machine
Replication in eukaryotic organisms
... mehr
Telomeres and telomerase: replication termination
RNA: Transcription and Processing
RNA
Transcription
Transcription in eukaryotes
Intron removal and exon splicing
Small functional RNAs that regulate and protect the eukaryotic genome
Proteins and Their Synthesis
Protein structure
The genetic code
tRNA: the adapter
Ribosomes
The proteome
Gene Isolation and Manipulation
Overview: isolating and amplifying specific gene fragments
Generating recombinant DNA molecules
Finding a specific clone of interest
Determining the base sequence of a DNA segment
Aligning genetic and physical maps to isolate specific genes
Genetic engineering
Regulation of Gene Expression in Bacteria and Their Viruses
Gene regulation
Discovery of the lac system: negative control
Catabolite repression of the lac operon: positive control
Dual positive and negative control: the arabinose operon
Metabolic pathways and additional levels of regulation: attenuation
Bacteriophage life cycles: more regulators, complex operons
Alternative sigma factors regulate large sets of genes
Regulation of Gene Expression in Eukaryotes
Transcriptional regulation in eukaryotes: an overview
Lessons from yeast: the GAL system
Dynamic chromatin
Short-term activation of genes in a chromatin environment
Long-term inactivation of genes in a chromatin environment
Gender-specific silencing of genes and whole chromosomes
Post-transcriptional gene repression by miRNAs
(...)
Telomeres and telomerase: replication termination
RNA: Transcription and Processing
RNA
Transcription
Transcription in eukaryotes
Intron removal and exon splicing
Small functional RNAs that regulate and protect the eukaryotic genome
Proteins and Their Synthesis
Protein structure
The genetic code
tRNA: the adapter
Ribosomes
The proteome
Gene Isolation and Manipulation
Overview: isolating and amplifying specific gene fragments
Generating recombinant DNA molecules
Finding a specific clone of interest
Determining the base sequence of a DNA segment
Aligning genetic and physical maps to isolate specific genes
Genetic engineering
Regulation of Gene Expression in Bacteria and Their Viruses
Gene regulation
Discovery of the lac system: negative control
Catabolite repression of the lac operon: positive control
Dual positive and negative control: the arabinose operon
Metabolic pathways and additional levels of regulation: attenuation
Bacteriophage life cycles: more regulators, complex operons
Alternative sigma factors regulate large sets of genes
Regulation of Gene Expression in Eukaryotes
Transcriptional regulation in eukaryotes: an overview
Lessons from yeast: the GAL system
Dynamic chromatin
Short-term activation of genes in a chromatin environment
Long-term inactivation of genes in a chromatin environment
Gender-specific silencing of genes and whole chromosomes
Post-transcriptional gene repression by miRNAs
(...)
... weniger
Autoren-Porträt von Anthony J. F. Griffiths, Susan R. Wessler, Sean B. Carroll, John Doebley
Anthony J.F. Griffiths, Susan R. Wessler, Sean B. Carroll and John Doebley
Bibliographische Angaben
- Autoren: Anthony J. F. Griffiths , Susan R. Wessler , Sean B. Carroll , John Doebley
- 2012, 10th ed., XXI, 802 Seiten, mit farbigen Abbildungen, mit Abbildungen, Maße: 15,6 x 23,4 cm, Gebunden, Englisch
- With Anthony J. F. Griffiths, Susan R. Wessler, Richard C. Lewontin et al.
- Verlag: Freeman
- ISBN-10: 1429276347
- ISBN-13: 9781429276344
Sprache:
Englisch
Rezension zu „Introduction to Genetic Analysis, International Edition “
'The author does an excellent job of showing how genetics is used today (one of the major strengths of the text).' - Kurt Dubear Kroening, University of Wisconsin, USA 'Its major strength is reflected in its title: that it introduces students to genetics as a mode of analysis. Not all students will become practicing geneticists, but what they can take away from learning through this text is how to construct knowledge by analyzing data and solving problems.' - Lynn A. Petrullo, College of New Rochelle, USA
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