Magnetic Resonance Imaging of Angiogenesis
(Sprache: Englisch)
If dynamic MRI is to be used for the selection of antivascular drugs that advance into efficacy trials, then it will be necessary to develop standardized approaches to measurement and robust analytic approaches with clear accepted endpoints specified...
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If dynamic MRI is to be used for the selection of antivascular drugs that advance into efficacy trials, then it will be necessary to develop standardized approaches to measurement and robust analytic approaches with clear accepted endpoints specified prospectively that have biological validity. Such developments will be essential for multicentre trials in which it will be necessary to establish effective cross-site standardization of measurements and evaluation. Furthermore, clinical trials will be subject to stringent regulations surrounding traceability and reproducibility that need to be followed before the regulatory authorities will accept the integrity of the data. This book addresses these issues based on experience gained over years of developing clinical trials methodology using dynamic MRI techniques. The editors elaborate on the techniques that are most validated, and describe tactics that need to be considered while preparing for multicentre clinical trials, including strategies to be adopted during the protocol planning and execution phases. Limitations of all these techniques are realistically explored.
Klappentext zu „Magnetic Resonance Imaging of Angiogenesis “
Magnetic Resonance Imaging of Angiogenesis is a unique book that explains the usage of angiogenesis/hypoxia imaging techniques in clinical trials and describes how imaging may be used to answer mechanistic questions on drug effects in tumours. The book answers all the questions raised during the planning, implementation and analysis in a DCE-MRI study. Its format is very helpful and intuitive, which makes it very easy for anyone to find a precise answer without having to go through lengthy book chapters and countless scientific articles. The book is an essential resource for all postgraduates, professionals, and trainees in radiology and oncology.Explains the use of MRI as a key investigative technique in research, and cancer therapy
Addresses issues based on experience gained over years of developing clinical trials methodology using dynamic MRI techniques.
Unique breakdown of key topics raised by clinicians working in the field
Well-known experts provide personal insights into common problems, and elaborate on the techniques that are most validated
The editors describe tactics that need to be considered while preparing for multicentre clinical trials, including strategies to be adopted during the protocol planning and execution phases, and explore limitations of all these techniques realistically
Autoren-Porträt von Anwar Padhani, David Collins
Anwar Padhani, MB BS FRCP FRCR. Consultant Radiologist and Head of Imaging Research, Paul Strickland Scanner Centre, Mount Vernon Hospital, Northwood, Middlesex, UK David C. Collins. Cancer Research UK Clinical Magnetic Resonance Research Group, Institute of Cancer Research and The Royal Marsden NHS Trust, Sutton, Surrey, UK
Bibliographische Angaben
- Autoren: Anwar Padhani , David Collins
- 1. Auflage, 352 Seiten, Maße: 16,8 x 24,4 cm, Gebunden, Englisch
- Herausgegeben: Anwar Padhani
- Verlag: Wiley & Sons
- ISBN-10: 0470515961
- ISBN-13: 9780470515969
Sprache:
Englisch
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