Management of Soft Tissue Sarcoma

3.         General Statement as to Efficacy Surgery / Chemotherapy / Radiation Therapy

·         Extent of primary surgery

·         Surgical Treatment of Local Recurrence

·         Diagnostic Imaging

·         Surgery for Metastatic Disease

o   Pulmonary Metastasis

o   Surgery and the Management of Sarcoma Liver Metastasis

·         Radiation Therapy

o   Adjuvant Radiation Therapy

o   Dose of Radiation Therapy

o   Adjuvant Brachytherapyo   Radiation Therapy in the Presence of Positive Microscopic Margins



o   Definitive Radiation Therapy

o   Radiation to Patients with Neurovascular Involvemento   Wound Complications of Radiation Therapy



o   Adjuvant and Neoadjuvant Chemotherapy for Soft Tissue Sarcomas

o   Sarcomas More Common in Adults

o   Larger Randomized Studies

o   Selected Meta-analyses of Randomized Trials of Adjuvant Chemotherapy

o   Adjuvant Therapy for GIST

o   Sarcomas More Common in Pediatric Setting

o   Brief comments regarding chemotherapy for metastatic soft tissue sarcoma

o   Newer Systemic Agents

·         Special Techniques for Primary & Locally Recurrent Disease

o   Intra-arterial Chemotherapy

o   Limb Perfusion and Hyperthermia

o   Immunotherapy for Sarcomas

<·         References

 

 

Part II   Management by Histopathology

 

4.                  Gastrointestinal stromal tumor

·         Imaging

·         Familial GIST

·         Natural History

·         Diagnosis / Molecular Pathology

·         Treatment

o Adjuvant Imatinib for Primary GIST

o Neoadjuvant Therapy for Primary Disease not amenable to Surgery<

o Treatment of Recurrence

o Imatinib: The First Small Molecule Oral Kinase Inhibitor for Metastatic GIST Failing Imatinib & Sunitinib

o Systemic Targeted Therapy for Metastatic GISTo Dose Intensity over Time



o Imatinib Pharmacokinetics

·         Second-Line Sunitinib for Imatinib-Resistant Metastatic GIST

o Other Tyrosine Kinase Inhibitors for Metastatic GIST

o Failing Imatinib and Sunitinib

o GRID Trial

·         Newer Agents for GIST

·         References

 

5.                  Liposarcoma

·         Imaging

·         Diagnosis

·         Treatment

·         Radiation Therapy for Liposarcoma·         Systemic Therapy: General Considerations



·         Adjuvant Therapy

·         Treatment of Metastatic Disease·         Outcome



·         Outcome Following Metastasis

·         References

 6.                  Leiomyosarcoma



·         Imaging

·         Diagnosis, Molecular Pathology

·         Primary Treatment

·         Radiation Therapy

·         Systemic Therapy

o   Adjuvant Chemotherapy for Leiomyosarcoma

·         Outcomes after Primary Therapy

·         Patterns of Recurrence

·         Treatment of Recurrence

·         Metastatic Disease

·         References

 

7.                  Undifferentiated Pleomorphic Sarcoma (UPS) (Malignant Fibrous Histiocytoma:  MFH) Myxofibrosarcoma

·         Imaging

·         Diagnosis, Molecular Pathology

·         Natural History

·         Treatment

·         Radiation Therapy

·         Metastatic Disease·         Adjuvant Chemotherapy



·         Outcome

·         References

 8.                  Synovial Sarcoma



·         Imaging

·         Diagnosis, Molecular Pathology

·         Treatment

·         Radiation Therapy

·         Chemotherapy

·         Treatment of Recurrence

o   Local Recurrence

o   Systemic Treatment

·         Outcome·         References



                  

9.                  Malignant Peripheral Nerve Sheath Tumor (MPNST) / Triton Tumor

·         Presentation

·         Imaging

·         Diagnosis, Pathology

·         Neurofibromatosis Type 1 and Outcome

·         Treatment

·         Radiation Therapy

·         Chemotherapy for MPNST·         Outcome



·         References

 

 

10.              Desmoid Tumor / Deep-Seated Fibromatosis (Desmoid-Type Fibromatosis)

·         Clinical Presentation

·         Imaging

·         Diagnosis, Molecular Pathology·         Natural History



·         Treatment

·         Treatment of Recurrence

<·         Systemic Therapy

·         Treatment by Observation

·         Radiation Therapy

·         Patterns of Failure

·         Outcome

·         References

 

11.              Solitary Fibrous Tumor / Hemangiopericytoma

·         Doege-Potter Syndrome

·         Primary Therapy

·         Systemic Therapy for Metastatic Disease

·         Outcome

·         References

 

12.              Fibrosarcoma and its Variants

·         Outcome

·         Dermatofibrosarcoma Protuberans

·         Outcome

·         Low-Grade Fibromyxoid Sarcoma (of Evans Tumor)

·         Outcome

·         Sclerosing Epithelioid Fibrosarcoma·         Inflammatory Myofibroblastic Tumor



·         Infantile Fibrosarcoma

·         Myxoinflammatory Fibroblastic Sarcoma / Inflammatory Myxohyaline Tumor of Distal Extremities·         Adult-Type Fibrosarcoma



·         References

 

13.              Vascular Sarcomas·         Epithelioid Hemangioendothelioma



·         Angiosarcoma / Lymphangiosarcoma

·         Outcome·         Kaposi Sarcoma



·         References

 

14.              Epithelioid Sarcoma

·         Outcome

·         References

 

15.              Sarcomas More Common in Children

Soft Tissue Sarcomas More Commonly Observed in Pediatric Patients
• Ewing Sarcoma Family of Tumors (EFT)
• Demographics
• Primary Therapy
• Adjuvant Chemotherapy
• High-Dose Systemic Therapy for Metastatic Disease
• Standard Cytotoxic Chemotherapy After Disease Relapse
• Investigational Approaches
• Ewing Sarcoma-Like Tumors
• Rhabdomyosarcoma
• Demographics
• Molecular Biology
• Risk Stratification
• Staging
• Imaging
Primary Therapy
• Chemotherapy for Metastatic Disease
• Embryonal Sarcoma
• References

 

16.              Radiation-Induced Sarcoma

·         References

 17.              Alveolar Soft Part Sarcoma



·         Imaging

·         Diagnosis, Molecular Pathology

·         Primary Treatment

·         Treatment of Metastatic Disease

·         Outcome

·         References

 

18.              Clear Cell Sarcoma / Melanoma of Soft Parts

·         Imaging

·         Diagnosis, Molecular Pathology

·         Treatment

·         Outcome

·        

 

19.              Desmoplastic Small Round Cell Tumor

·         Imaging

·         Diagnosis

·         Treatment

·         Outcome

·         References

 

20.              Extraskeletal Myxoid Chondrosarcoma

·         Imaging

·         Diagnosis·         Treatment



·         Outcome

·         Mesenchymal Chondrosarcoma

·         References

 

21.              Other Uterine Sarcomas

·         Low Grade Endometrial Stromal Sarcoma

o   Diagnosis

o   Treatment 

o   Outcome

·         High Grade Endometrial Stromal Sarcomao   Outcome



·         Undifferentiated Uterine Sarcoma (UUS)

·         Uterine Carcinosarcomas and Other Malignant Mixed Müllerian Tumors·         PEComas



o   Outcome

·         References

 

22.              Extraskeletal Osteogenic Sarcoma

·         Imaging

·         Diagnosis

·         Treatment

·         Outcome

·         References

 

23.              Sustentacular Tumors of Lymph Tissue

·         Follicular Dendritic Cell Tumor (Dendritic Reticulum Cell Tumor [FDCT]) and Interdigitating Reticulum Cell Tumor (IDRCT)

·         True Histiocytic Sarcoma

·         Langerhans Cell Tumors

·         Outcome

·         References

 

24.              Uncommon / Unique Sites

·         Heart and Great Vessels

·         Primary Sarcomas of the Breast

o   Phylloides Tumoro   Diagnosis



o   Outcome

·         Head and Neck

o   Treatment

·         Primary Sarcomas of the Mediastinum

·         Liver

·        

 

 

Part III           Benign and Less Aggressive Lesions

 

25.              Mostly Benign / Rarely Metastasizing

·         Ossifying Fibromyxoid Tumor

·         Perivascular Epithelial Cell Tumor (PEComa) & Related Entities,  Lymphangioleiomyomatosis, Angiomyolipoma, and Sugar Cell Tumor

·         Therapy

·         Giant Cell Tumor of Tendon Sheath / Pigmented Villonodular Synovitis

·         Myoepithelioma of Soft Tissue

·         Glomus tumor <·         References

                         

26.              Benign Tumors

·         Lipoma          ·         Lipomatosis  



·         Lipoblastoma / Lipoblastomatosis

·         Angiolipoma

·         Angiomyolipoma

·         Angiomyelolipoma

·         Hibernoma

·         Elastofibroma

·         Granular Cell Tumor

·         Hemangioma

·         Leiomyoma

·         Schwannoma

·         Neurofibroma

·         Myxoma

·         Angiomyxoma

·         Angiofibroma

·         References

 

27.              Reactive Lesions·         Myositis Ossificans



·         Nodular Fasciitis                  

·         Sarcoma Masquerade

·         References

 

 

 

Suggested Keywords

 

Index