Membrane Transporters
Methods and Protocols
(Sprache: Englisch)
This collection of cutting-edge methodologies for studying membrane transporters and channels takes advantage of all the latest developments in biomedical research, including pharmacogenomcs, bioinformatics, and microarray technologies. The authors explain...
Voraussichtlich lieferbar in 3 Tag(en)
versandkostenfrei
Buch (Kartoniert)
106.99 €
Produktdetails
Produktinformationen zu „Membrane Transporters “
This collection of cutting-edge methodologies for studying membrane transporters and channels takes advantage of all the latest developments in biomedical research, including pharmacogenomcs, bioinformatics, and microarray technologies. The authors explain databases and tools for bioinformatics studies, provide practical guidelines for microarray experiments and data analysis, and illustrate the use of small angle X-ray scattering, nuclear magnetic resonance (NMR), and molecular modeling to study the structural biology of membrane transporters. Methods for exploring structure-function correlation, such as site-directed mutagenesis, immunocytochemistry, and confocal microcopy are also described, along with several that may help in the development of novel therapeutics.
Klappentext zu „Membrane Transporters “
Studies of membrane transporters have had great impact on our und- standing human diseases and the design of effective drugs. About 30% of current clinically marketed drugs are targeting membrane transporters or channels. Membrane Transporters: Methods and Protocols provides various practical methodologies for the ongoing research on membrane transporters. To provide readers the most up-to-date information, several emerging fields and methodologies are embraced in this book, including pharmacogenomics, bioin-formatics, and microarray technology. Pharmacogenomics studies of membrane transporters are useful in drug discovery and in predicting drug responses in the clinic. In this volume, the current status of pharma- genomics studies of transporters is reviewed and research methodologies in this field are described. Transporter classification is important in studying the structure and function of membrane transporters and has thus triggered intensive interest in recent years. Membrane Transporters: Methods and Protocols provides a systematic classification of all transmembrane transport proteins found in living org- isms on Earth. This classification system will be helpful for further studies on various aspects of membrane transporters, especially for such large-scale gene expression studies as those employing microarray technologies. Bioinformatics is frequently used in transporter studies and has become indispensable for all kinds of research methods. Commonly used bio- formatics methods, such as databases and tools for sequence analysis and - tif studies, are explained in order to facilitate membrane transporters research. Because of heterogeneous sources and tremendous amounts of data, data in- gration has become one of the most important issues in transporter studies.
Inhaltsverzeichnis zu „Membrane Transporters “
Pharmacogenomics of Membrane Transporters.- The IUBMB-Endorsed Transporter Classification System.- Bioinformatics and Data Integration in Membrane Transporter Studies.- DNA Microarrays to Analyze Gene Expression in Animals with Altered Transporter Expression.- Microarray Data Analysis in Studies of Membrane Transporters.- Laser Capture Microdissection to Examine Transporter Expression in Specific Cell Regions.- Site-Directed Mutagenesis in the Study of Membrane Transporters.- Fluorescence Techniques for Studying Membrane Transport Proteins.- Reconstitution of Membrane Transporters.- Equilibrium Binding and Transport Studies.- Electrophysiological Studies of Ion Channels and Therapeutic Potential With Adenovirus-Mediated Gene Transfer.- Antibody Production and Immunocytochemical Localization of Amino Acid Transporters.- Xenopus laevis Oocytes.- Measurement of Intracellular pH.- Small-Angle X-Ray Scattering Studies of Membrane Transporter Peripheral Components and Soluble Domains.- Membrane Protein NMR Studies.- Analysis of Soluble Sugar Permease Domains by Solution NMR.- Molecular Modeling and Molecular Dynamics Simulations of Membrane Transporter Proteins.- Imaging Plasma Membrane Proteins by Confocal Microscopy.
Bibliographische Angaben
- 2010, XII, 372 Seiten, Maße: 15,2 x 22,9 cm, Kartoniert (TB), Englisch
- Herausgegeben: Qing Yan
- Verlag: Springer, Berlin
- ISBN-10: 1617373591
- ISBN-13: 9781617373596
Sprache:
Englisch
Rezension zu „Membrane Transporters “
"The book is a useful reference to have for bench scientists. The protocols provide a good starting point for someone seeking technical advice for various procedures used to study transport."-Doody's Health Sciences Book Review Journal"...a valuable laboratory or office protocols book that combines, distils and updates traditional and novel bench and in silico techniques for the study of membrane transporters." - Clinical and Experimental Pharmacology and Physiology
Pressezitat
"The book is a useful reference to have for bench scientists. The protocols provide a good starting point for someone seeking technical advice for various procedures used to study transport."-Doody's Health Sciences Book Review Journal"...a valuable laboratory or office protocols book that combines, distils and updates traditional and novel bench and in silico techniques for the study of membrane transporters." - Clinical and Experimental Pharmacology and Physiology
Kommentar zu "Membrane Transporters"
0 Gebrauchte Artikel zu „Membrane Transporters“
Zustand | Preis | Porto | Zahlung | Verkäufer | Rating |
---|
Schreiben Sie einen Kommentar zu "Membrane Transporters".
Kommentar verfassen