Modern HPLC for Practicing Scientists
(Sprache: Englisch)
A comprehesive yet concise guide to Modern HPLCWritten for practitioners by a practitioner, Modern HPLC for Practicing Scientists is a concise text which presents the most important High-Performance Liquid Chromatography (HPLC) fundamentals, applications,...
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A comprehesive yet concise guide to Modern HPLCWritten for practitioners by a practitioner, Modern HPLC for Practicing Scientists is a concise text which presents the most important High-Performance Liquid Chromatography (HPLC) fundamentals, applications, and developments. It describes basic theory and terminology for the novice, and reviews relevant concepts, best practices, and modern trends for the experienced practitioner. Moreover, the book serves well as an updated reference guide for busy laboratory analysts and researchers.Topics covered include: HPLC operation Method development Maintenance and troubleshooting Modern trends in HPLC such as quick-turnaround and "greener" methods Regulatory aspectsWhile broad in scope, this book focuses particularly on reversed-phase HPLC, the most common separation mode, and on applications for the pharmaceutical industry, the largest user segment. Accessible to both novice and intermedate HPLC users, information is delivered in a straightforward manner illustrated with an abundance of diagrams, chromatograms, tables, and case studies, and supported with selected key references and Web resources.With intuitive explanations and clear figures, Modern HPLC for Practicing Scientists is an essential resource for practitioners ofall levels who need to understand and utilize this versatile analytical technology.
Inhaltsverzeichnis zu „Modern HPLC for Practicing Scientists “
Preface.1 Introduction.
1.1 Introduction.
1.2 Modes of HPLC.
1.3 Some Common-Sense Corollaries.
1.4 How to Get More Information.
1.5 Summary.
1.6 References.
2 Basic Terms and Concepts.
2.1 Scope.
2.2 Basic Terms and Concepts.
2.3 Mobile Phase.
2.4 The Resolution Equation.
2.5 The Van Deemter Equation.
2.6 Isocratic vs. Gradient Analysis.
2.7 Concept of Orthogonality.
2.8 Sample Capacity.
2.9 Glossary of HPLC Terms.
2.10 Summary and Conclusion.
2.11 References.
3 HPLC Columns and Trends.
3.1 Scope.
3.2 General Column Description and Characteristics.
3.3 Column Types.
3.4 Column Packing Characteristics.
3.5 Modern HPLC Column Trends.
3.6 Guard Columns.
3.7 Specialty Columns.
3.8 Column Selection Guides.
3.9 Summary.
3.10 References.
3.11 Internet Resources.
4 HPLC Instrumentation and Trends.
4.1 Introduction.
4.2 HPLC Solvent Delivery Systems.
4.3 Injectors and Autosamplers.
4.4 Detectors.
4.5 UV/VIS Absorbance Detectors.
4.6 Photodiode Array Detectors.
4.7 Other Detectors.
4.8 Hyphenated and Specialized Systems.
4.9 HPLC Accessories and Data Handling Systems.
4.10 Instrumental Bandwidth (IBW).
4.11 Trends in HPLC Equipment.
4.12 Manufacturers and Equipment Selection.
4.13 Summary.
4.14 References.
4.15 Internet Resources.
5 HPLC Operation Guide.
5.1 Scope.
5.2 Safety and Environmental Concerns.
5.3 Mobile Phase Preparation.
5.4 Best Practices in HPLC System Operation.
5.5 From Chromatograms to Reports.
5.6 Summary of HPLC Operation.
5.7 Guides on Performing Trace Analysis.
5.8 Summary.
5.9 References.
6 Pharmaceutical Analysis.
6.1 Introduction.
6.2 Identification.
6.3 Assays.
6.4 Impurity Testing.
6.5 Dissolution Testing.
6.6 Cleaning Validation.
6.7 Bioanalytical Testing.
6.8 Chiral Analysis.
6.9 Case Study: HPLC Methods in Early Development.
6.10
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Summary.
6.11 References.
7 Food, Environmental, Chemical, and Life Sciences Applications.
7.1 Introduction.
7.2 Food Applications.
7.3 Environmental Applications.
7.4 Chemical, GPC and Plastics Applications.
7.5 Ion Chromatography.
7.6 Life Sciences Applications.
7.7 Summary.
7.8 References.
8 HPLC Method Development.
8.1 Introduction.
8.2 Defining Method Types and Goals.
8.3 Gathering Sample and Analyte Information.
8.4 Initial HPLC Method Development.
8.5 Method Fine-Tuning.
8.6 Phase-Appropriate Method Development.
8.7 Method Development Software Tools.
8.8 Case Studies.
8.9 Summary and Conclusions.
8.10 References.
9 Regulatory Aspects of HPLC Analysis: HPLC System and Method Validation.
9.1 Introduction.
9.2 HPLC System Qualification.
9.3 Method Validation.
9.4 System Suitability Testing (SST).
9.5 Case Study on Method Validation.
9.6 Cost-Effective Regulatory Compliance.
9.7 Summary and Conclusions.
9.8 References.
9.9 Internet Resources.
10 HPLC Maintenance and Troubleshooting Guide.
10.1 Scope.
10.2 HPLC System Maintenance.
10.3 HPLC Troubleshooting.
10.4 Case Studies.
10.5 Summary and Conclusion.
10.6 References.
10.7 Internet Resources.
11 Modern Trends in HPLC.
11.1 Columns: Shorter and Narrower Packed with Small Particles.
11.2 Column Packing: Novel Bonded Phases.
11.3 Pumps.
11.4 Autosamplers.
11.5 Detectors.
11.6 HPLC Systems.
11.7 Lab-on-a-Chip.
11.8 Data Handling.
11.9 Regulatory Compliance.
11.10 Greener HPLC Methods.
11.11 Summary and Conclusions.
11.12 References.
Index.
6.11 References.
7 Food, Environmental, Chemical, and Life Sciences Applications.
7.1 Introduction.
7.2 Food Applications.
7.3 Environmental Applications.
7.4 Chemical, GPC and Plastics Applications.
7.5 Ion Chromatography.
7.6 Life Sciences Applications.
7.7 Summary.
7.8 References.
8 HPLC Method Development.
8.1 Introduction.
8.2 Defining Method Types and Goals.
8.3 Gathering Sample and Analyte Information.
8.4 Initial HPLC Method Development.
8.5 Method Fine-Tuning.
8.6 Phase-Appropriate Method Development.
8.7 Method Development Software Tools.
8.8 Case Studies.
8.9 Summary and Conclusions.
8.10 References.
9 Regulatory Aspects of HPLC Analysis: HPLC System and Method Validation.
9.1 Introduction.
9.2 HPLC System Qualification.
9.3 Method Validation.
9.4 System Suitability Testing (SST).
9.5 Case Study on Method Validation.
9.6 Cost-Effective Regulatory Compliance.
9.7 Summary and Conclusions.
9.8 References.
9.9 Internet Resources.
10 HPLC Maintenance and Troubleshooting Guide.
10.1 Scope.
10.2 HPLC System Maintenance.
10.3 HPLC Troubleshooting.
10.4 Case Studies.
10.5 Summary and Conclusion.
10.6 References.
10.7 Internet Resources.
11 Modern Trends in HPLC.
11.1 Columns: Shorter and Narrower Packed with Small Particles.
11.2 Column Packing: Novel Bonded Phases.
11.3 Pumps.
11.4 Autosamplers.
11.5 Detectors.
11.6 HPLC Systems.
11.7 Lab-on-a-Chip.
11.8 Data Handling.
11.9 Regulatory Compliance.
11.10 Greener HPLC Methods.
11.11 Summary and Conclusions.
11.12 References.
Index.
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Autoren-Porträt von Michael W. Dong
MICHAEL W. DONG , PhD, is a Research Director at Synomics Pharma in Wareham, Massachusetts,responsible for chromatography method development and research studies. He has been a research fellow/group leader at Purdue Pharma, a senior staff scientist at PerkinElmer, and a section head at Hoechst Celanese. He holds a BSc in chemistry from Brooklyn College and a PhD in analytical chemistry from the City University of New York Graduate Center. Dr. Dong pioneered Fast LC and has over eighty publications in chromatography and analytical chemistry. He is the coeditor of another book on pharmaceutical analysis by HPLC, published in 2005.
Bibliographische Angaben
- Autor: Michael W. Dong
- 2006, 1. Auflage, 304 Seiten, Maße: 23,5 cm, Kartoniert (TB), Englisch
- Verlag: Wiley & Sons
- ISBN-10: 047172789X
- ISBN-13: 9780471727897
Sprache:
Englisch
Pressezitat
"This reasonably priced HPLC primer provides sound and authoritative guidance..." ( E-STREAMS , June 2007)
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