UNI-MED Science / Modern Laboratory Investigation of Thyroid Diseases
(Sprache: Englisch)
Laboratory examinations are an essential part of the diagnostic investigation of thyroid diseases. They range from assays of the thyroid hormones and thyroid-stimulating hormone, through antibody investigations, to tumour markers. Over the past years there...
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Klappentext zu „UNI-MED Science / Modern Laboratory Investigation of Thyroid Diseases “
Laboratory examinations are an essential part of the diagnostic investigation of thyroid diseases. They range from assays of the thyroid hormones and thyroid-stimulating hormone, through antibody investigations, to tumour markers. Over the past years there have been various innovations that are relevant to the investigation of thyroid diseases and that have therapeutic implications. They include, in particular, antibody investigations, including the determination of TSH-receptor antibodies but also the introduction of highly sensitive thyroglobulin assays. This book summarises established and new developments in the laboratory investigation of thyroid diseases and is a useful guide to clinical practice with material that is right up-to-date.
Inhaltsverzeichnis zu „UNI-MED Science / Modern Laboratory Investigation of Thyroid Diseases “
1. Assay methods and clinical test procedures 121.1. General assay procedures for thyroid diseases 121.2. Thyroid hormones 131.2.1. Thyroid-stimulating hormone (TSH, thyrotropin) 131.2.1.1. TSH screening in neonates 141.2.1.2. TRH test (TSH stimulation test with TRH) 141.2.2. Determination of free thyroxine (fT4, tetraiodothyronine) and free triiodothyronine (fT3) 151.2.3. Determination of total thyroxine (TT4, total tetraiodothyronine) and total triiodothyronine (TT3) 161.3. Thyroxine-binding globulin (TBG) 171.4. Reverse T3 (rT3) 171.5. Thyroid autoantibodies 181.5.1. Thyroid peroxidase antibodies (anti-TPO antibodies) 181.5.2. Thyroglobulin antibodies (anti-hTG antibodies, TAbs) 181.5.3. Thyroid autoantibodies to the TSH receptor (TRAb, anti-TSHR Ab) 181.6. Tumour markers 191.6.1. Thyroglobulin (hTG) 191.6.2. Calcitonin (hCT, thyrocalcitonin) 201.6.2.1. Pentagastrin stimulation test 201.6.2.2. Calcium stimulation test 211.6.3. Chromogranin A (CgA) 211.7. References 222. Euthyroid goitre 242.1. Introduction and definition 242.2. Aetiology 242.3. Clinical presentation 242.4. Laboratory investigations 242.4.1. Synthesis, homeostasis and protein binding of thyroid hormones 242.4.2. Confounders 252.4.3. Clinical interpretation of test results 262.4.4. Reference ranges 262.4.5. Reference ranges and their relationship with age 262.4.6. Calcitonin determination in the context of cold thyroid nodules 272.5. References 273. Hyperthyroidism 303.1. Introduction and definition 303.2. Aetiology 303.3. Clinical presentation 303.4. Laboratory investigations 303.4.1. Methods of determination 303.4.2. Thyroid hormones 303.4.3. Hyperthyroidism and pregnancy 313.4.4. Postpartum thyroiditis 323.4.5. Amiodarone-induced hyperthyroidism 323.5. References 324. Graves' (Basedow's) disease 364.1. Introduction and definition 364.2. Aetiology 364.3. Clinical presentation 374.4. Laboratory investigations 384.4.1. Autoantibodies to the TSH receptor 384.4.1.1. Early TRAb assays 384.4.1.2.
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Fluid-phase TRAb assays (first generation) 394.4.1.3. Solid-phase TRAb assays (second generation) 394.4.1.4. M22-based TRAb assays (third generation) 404.4.1.5. TRAb bioassays 404.4.2. Autoantibodies to thyroglobulin and autoantibodies to thyroid peroxidase 414.4.2.1. Clinical importance of TRAbs in the diagnosis and monitoring of Graves' disease 414.4.2.2. Clinical importance of TPO antibodies and TAbs in Graves' disease 434.5. Summary 434.6. References 435. Endocrine ophthalmopathy 465.1. Introduction and definition 465.2. Aetiology 465.3. Clinical manifestation and classification of EO 465.4. Laboratory investigations 495.4.1. TSH, fT4, fT3 495.4.2. Thyroid-specific antibodies 495.5. Management plan for EO 515.6. References 516. Hypothyroidism 546.1. Introduction and definition 546.2. Aetiology 546.3. Clinical presentation 546.4. Laboratory investigations 546.4.1. Thyroid hormones 546.4.2. Non-thyroidal illness syndrome 546.4.3. Thyroid autoantibodies 556.4.4. Assessment of prognosis in autoimmune thyroiditis 566.4.5. Congenital hypothyroidism 566.5. References 577. Thyroid carcinomas of follicular cell origin 607.1. Introduction and definition 607.2. Aetiology 607.3. Clinical presentation 617.4. Laboratory investigations 617.5. References 668. Medullary thyroid carcinoma 708.1. Introduction and definition 708.2. Aetiology 708.3. Clinical presentation 718.4. Laboratory investigations 718.4.1. Calcitonin as a tumour marker in thyroid nodules (calcitonin screening) 738.4.2. Calcitonin as a tumour marker in treated MTC 738.5. References 759. Abbreviations 78 Index 79
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Bibliographische Angaben
- Autor: Matthias Schott
- 2012, 1st ed., 16 Abbildungen, Maße: 17,4 x 24,6 cm, Gebunden, Englisch
- Verlag: UNI-MED, Bremen
- ISBN-10: 3837413233
- ISBN-13: 9783837413236
- Erscheinungsdatum: 10.10.2014
Sprache:
Englisch
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