Molecular Biology of RNA
(Sprache: Englisch)
For many years, RNA was thought to have something of a supplementary role in genome function - an intermediate in the flow of biological information from gene to protein. In recent years, however, the centrality of RNA as a key player in gene expression has...
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Klappentext zu „Molecular Biology of RNA “
For many years, RNA was thought to have something of a supplementary role in genome function - an intermediate in the flow of biological information from gene to protein. In recent years, however, the centrality of RNA as a key player in gene expression has become clear; it is far from being merely a staging post between gene and protein. Instead, new insights into RNA structure and function have revolutionized our view of molecular biology, and the role of RNA inthe evolution of life itself.
Molecular Biology of RNA is the first student text to provide a broad survey of RNA structure and function. It leads the reader through the life cycle of an RNA, placing particular emphasis on post-transcriptional events - including post-transcriptional processing and splicing - to reveal how hugely diverse gene products stem from a relatively modest gene pool. It also describes how RNA molecules have a range of biological functions beyond that of the messenger RNA, including roles as
catalysts and regulatory molecules.
Throughout the book, descriptions of our current understanding of the field are augmented with examples of pioneer RNA researchers and their key experiments, demonstrating how we have reached our current level of understanding. Further, boxes illustrate the involvement of RNA in the aetiology of human disease, showing how an understanding of the molecular biology of RNA is central to understanding disease processes and their potential treatment.
Molecular Biology of RNA is an essential course text for molecular biology students in the 21st century, capturing the excitement of a field that has changed our understanding of genome function forever.
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Inhaltsverzeichnis zu „Molecular Biology of RNA “
1: Introduction; 2: The versatility of RNA structure; 3: RNA catalysis; 4: The RNA binding proteins; 5: Capping, cleavage and nuclear polyadenylation; 6: Pre-mRNA splicing nuts and bolts; 7: How Pre-mRNAs are decoded by the splicing machinery; 8: Regulated pre-mRNA processing - alternative splicing; 9: Alternative splicing in development and disease; 10: Nucleocytoplasmic traffic of mRNA; 11: Nucleocytoplasmic traffic of non-coding RNA; 12: Messenger RNA localisation; 13: Messenger RNA translation; 14: Messenger RNA stability and decay; 15: RNA editing; 16: rRNA and tRNA processing; 17: Long non-coding RNAs; 18: RNA interference and short non-coding RNAs
Autoren-Porträt von David Elliott, Michael Ladomery
David Elliott is a Reader in Genetics at the Institute of Human Genetics, Newcastle University, UKMichael Ladomery is Principal Investigator in the RNA Biology group, School of Life Sciences, University of the West of England, UK.
Bibliographische Angaben
- Autoren: David Elliott , Michael Ladomery
- 2010, IX, 441 Seiten, 136 farbige Abbildungen, Maße: 18,9 x 26,4 cm, Kartoniert (TB), Englisch
- Verlag: Oxford University Press
- ISBN-10: 0199288372
- ISBN-13: 9780199288373
Sprache:
Englisch
Rezension zu „Molecular Biology of RNA “
All aspects of RNA biology are described clearly... One type of molecule, one book, up to date... A book on RNA like this is just in time. I am planning to start a MSc course on just RNA and this would be the book to use. |s Dr J Kooter, Vrije Universiteit Amsterdam
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