Molecular Imprinting

Aus dem Inhalt:
Preface
INTRODUCTION
Importance of Receptor Molecules in Advanced Science and Technology
Naturally Ocurring Receptors
Artificial Receptors
Receptors for Practical Applications
Why is the Molecular Imprinting Method so Promising?
FUNDAMENTALS OF MOLECULAR IMPRINTING
Introduction
General Principle of Molecular Imprinting
Covalent Imprinting and Non-covalent Imprinting
Advantages and Disadvantages of Covalent and Non-Covalent Imprinting
History
EXPERIMENTAL METHODS (I)
Introduction
Reagents and Experimental Procedures
Covalent Imprinting
Non-covalent Imprinting
"Dummy Molecular Imprinting"
EXPERIMENTAL METHODS (II)
Chromatographic Experiments
Batch-wise Guest-binding Experiments
Determination of Guest-binding Constants
SPECTROSCOPIC ANATOMY OF MOLECULAR IMPRINTING REACTIONS
Structures of Adducts in the Pre-organization Step
Determination of the Binding Constant k for the Formation of Monomer-template Adducts
Relationship between k Value and Imprinting Efficiency
Structure of the Guest-binding Site
FLOW-CHART OF A TYPICAL MOLECULAR IMPRINTING
Choice of Agents
Polymerization
Packing of Imprinted Polymers on HPLC Columns
Quantitative Evaluation of Imprinting Efficiency
PRACTICAL APPLICATIONS
High Performance Chromatography
Sensors
Biotechnology
Pharmacy
Therapy
Food Industry
Others
RECENT CHALLENGES AND PROGRESS
Imprinting and Guest-binding in Water
Preparation of Catalysts
Recognition of Proteins and Other Nano-scaled Guests
Surface Modification
CONCLUSIONS AND PROSPECTS
Index

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