Nephrotoxic Mechanisms of Drugs and Environmental Toxins
(Sprache: Englisch)
The majority of the offending toxicants to be reviewed in this volume were devel oped to help mankind, and it is only with prolonged or widespread application that their adverse effects have been recognized. Conversely, in the case of pre scrip tion drugs,...
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The majority of the offending toxicants to be reviewed in this volume were devel oped to help mankind, and it is only with prolonged or widespread application that their adverse effects have been recognized. Conversely, in the case of pre scrip tion drugs, there has been an attempt to identify the adverse effects in advance and incorporate these risks into the decision of approval for human consumption. Unfortunately, for those drugs in which recognized injury occurs only after prolonged use, such appraisals are made in retrospect. Despite this, most renal injury induced by drugs or toxicants can be either prevented by excluding drugs with unacceptable side effects or interrupted by eliminating the offending agent once damage is manifested. The fact that prevention, reversibility, or arrest of renal injury is possible provided a major impetus for this publication. Since no international registry for nephrotoxic injury exists, estimates of incidence must rely on less than ideal sources. Recently I, together with Dr. William Bennett, summarized a survey of the frequency of various categories of nephrologic disease (Porter and Bennett, 1981). Based on this survey, we projected that in nearly one of ten patients seeking nephrologic consultation a nephrotoxic etiology may be involved. Of cases of end-stage renal disease, between 3 and 4% are due to drug nephrotoxicity, according to recent published results(European Dialysis and Transplant Association, 1979). For acute renal failure, antibiotics and contrast agents persist as major offending agents, while for chronic renal failure, analgesics remain a worldwide problem.
Inhaltsverzeichnis zu „Nephrotoxic Mechanisms of Drugs and Environmental Toxins “
Section I. Pathophysiology of Acute Renal Failure1. Overview of Pathophysiology of Acute Renal Failure
2. Pathology of Acute Renal Failure
3. Effect of Heavy Metals on Sodium Transport in Vitro
4. Renal Hemodynamics in Nephrotoxic Acute Renal Failure
5. The Glomerulus in Acute Renal Failure
6. Heavy Metal Models of Experimental Acute Renal Failure
7. Studies on Segmental Transport in Models of Acute Renal Failure
8. Enhancement of Renal Regeneration by Amino Acid Administration
9. Amphotericin B Toxicity for Epithelial Cells
Section II. Renal Failure Due to Antimicrobial Agents
10. Antibiotic Nephrotoxicity: An Overview
11. Functional Considerations in Aminoglycoside Nephrotoxicity
12. Aminoglycoside Nephrotoxicity: Lysosomal and Mitochondrial Alterations in Rat Kidneys after Aminoglycoside Treatment
13. Aminoglycoside Interactions with Other Drugs: Clinical and Toxicologic Implications
14. Nephrotoxicity of Cephalosporin Antibiotics: Mechanisms and Modifying Factors
15. Tetracycline Nephrotoxicity
Section III. Tubulointerstitial Nephropathy Due to Drugs and Environmental Toxicants
16. Tubulointerstitial Nephropathy: An Overview
17. Current Concepts of Tubulointerstitial Nephritis
18. Analgesic Nephropathy: Clinical and Epidemiologic Factors
19. Analgesic Nephropathy: Renal Drug Distribution and Metabolism
20. Endemic Balkan Nephropathy
21. Nephrotoxicity of Natural Products: Mycotoxin-Induced Nephropathy
22. Lead Nephrotoxicity
23. The Rat as an Animal Model of Lead Nephropathy
Section IV. Pathophysiologic Mechanisms of Toxicity Induced by Environmental Toxins Jerry
24. Environmental Toxicities and Hazards: Introduction
25. Metabolism of Cadmium
26. Cadmium Nephropathy
27. Ultrastructural and Biochemical Localization of Organelle Damage from Nephrotoxic Agents
28. Mechanisms of Acute Nephrotoxicity: Halogenated Aliphatic Hydrocarbons
29. Potentiation of the Action of Nephrotoxic Agents by Environmental Contaminants
30.
... mehr
Alteration of Chloroform-Induced Nephrotoxicity by Exogenous Ketones
Section V. Immunologic Mechanisms and Toxic Nephropathies
31. Drug-Induced Renal Lesions: Immunopathologic Mechanisms
32. Antihistone Antibodies Induced by Procainamide and Hydralazine
33. Drug- and Toxin-Induced Nephritides: Anti-Kidney Antibody and Immune Complex Mediation
34. Immunological Mechanisms in Drug-Induced Acute Interstitial Nephritis
35. Drug-Induced Nephritides: Immediate Hypersensitivity Mechanism
36. Gold-Induced Autoimmune Reactions
37. Mercuric Chloride-Induced Immunologically Mediated Diseases in Experimental Animals
38. Genetic Control of Mercury-Induced Immune Response in the Rat
39. The Application of a Radioimmunoassay for Sensitive Detection of Metallothionein (Thionein) in Physiologic Fluid of Humans and Rats
Section V. Immunologic Mechanisms and Toxic Nephropathies
31. Drug-Induced Renal Lesions: Immunopathologic Mechanisms
32. Antihistone Antibodies Induced by Procainamide and Hydralazine
33. Drug- and Toxin-Induced Nephritides: Anti-Kidney Antibody and Immune Complex Mediation
34. Immunological Mechanisms in Drug-Induced Acute Interstitial Nephritis
35. Drug-Induced Nephritides: Immediate Hypersensitivity Mechanism
36. Gold-Induced Autoimmune Reactions
37. Mercuric Chloride-Induced Immunologically Mediated Diseases in Experimental Animals
38. Genetic Control of Mercury-Induced Immune Response in the Rat
39. The Application of a Radioimmunoassay for Sensitive Detection of Metallothionein (Thionein) in Physiologic Fluid of Humans and Rats
... weniger
Bibliographische Angaben
- Autor: George A. Porter
- 2012, Softcover reprint of the original 1st ed. 1982., 466 Seiten, Maße: 25,4 cm, Kartoniert (TB), Englisch
- Verlag: Springer
- ISBN-10: 1468442163
- ISBN-13: 9781468442168
Sprache:
Englisch
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