Springer Theses / New Gold-Catalyzed Reactions and Applications for the Synthesis of Alkaloids
(Sprache: Englisch)
This book presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1.6-enynes using gold (I) complexes. The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells.
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This book presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1.6-enynes using gold (I) complexes. The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells.
Klappentext zu „Springer Theses / New Gold-Catalyzed Reactions and Applications for the Synthesis of Alkaloids “
Ana Escribano Cuesta's thesis presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1,6-enynes using gold (I) complexes. An important part of the work involved streamlining the variables that allow the selective synthesis of different products such as tricyclic compounds, dihydropyrans, 1,3-dienes or cyclobutenes. The second chapter highlights the importance and difficulties in synthesising a cyclobutene subunit and the author includes a detailed description of how the products were prepared. The final chapter outlines the synthesis of lundurines using methodology developed by the author's research group for intramolecular gold-catalyzed cyclization of indoles with alkynes. The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells. The work in this thesis has led to a number of publications in high-profile chemistry journals.
Inhaltsverzeichnis zu „Springer Theses / New Gold-Catalyzed Reactions and Applications for the Synthesis of Alkaloids “
Introduction.- General Objectives.- Gold(I)-Catalyzed Reactions of 1,6-Enynes with Aldehydes: Cycloaddition versus Metathesis-Type Reactions.- Formation of Cyclobutene Compounds via Gold(I)-Catalyzed Cycloisomerization of 1,n-Enynes.- Approach Toward the Total Synthesis of Lundurines.
Bibliographische Angaben
- Autor: Ana Escribano Cuesta
- 2013, 2013, XIII, 195 Seiten, Maße: 16,6 x 24,2 cm, Gebunden, Englisch
- Verlag: Springer, Berlin
- ISBN-10: 3319007017
- ISBN-13: 9783319007014
Sprache:
Englisch
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