NMR of Biomolecules

Website: www.wiley-vch.de/home/nmrbiomolINTRODUCTIONNMR and its place in Mechanistic Systems Biology (Bertini, McGreevy, Parigi)The structure of biomolecules: fundamentalsStructural features of proteins (Banci, Cantini)Structural features of nucleic acids (Cevec, Jonker, Nozinovic, Richter, Schwalbe)What can be learned about the structure and dynamics of biomolecules from NMRProteins studied by NMR (Ferella, Rosato, Turano)Nucleic acids studied by NMR (Plavec)THE ROLE OF NMR IN THE STUDY OF THE STRUCTURE AND DYNAMICS OF BIOMOLECULESDetermination of protein structure and dynamics (Ferella, Rosato, Turano)DNA (Plavec)RNA (Stefl, Sklenár)Intrinsically disordered proteins (Felli, Pierattelli, Tompa)Paramagnetic molecules (Bertini, Luchinat, Parigi)THE ROLE OF NMR IN THE STUDY OF THE STRUCTURE AND DYNAMICS OF BIOMOLECULAR INTERACTIONSNMR methodologies for the analysis of protein interactions (Madl, Sattler)Metal-mediated interactions (Ciofi-Baffoni)Protein-paramagnetic protein interactions (Keizers, Hiruma, Ubbink)Protein-RNA interactions (Manoharan, Perez-Canadillas, Ramos)Protein-DNA interactions (Kovacic, Boelens)NMR IN DRUG DISCOVERYHigh-throughput screening and fragment-based design: general considerations for lead discovery and optimization (Pellecchia)Ligand-observed NMR in fragment-based approaches (Sledz, Abell, Ciulli)Interactions of metallodrugs with DNA (Sadler)RNA as a drug target (Ferner, Duchardt-Ferner, Rinnenthal, Buck, Wöhnert, Schwalbe)Fluorine NMR spectroscopy for biochemical screening in drug discovery (Dalvit)NMR of peptides (Beck, Frank, Kessler)SOLID-STATE NMRBiomolecular solid state NMR - basics (Barbet-Massin, Pintacuda)Protein dynamics in the solid-state (Lewandowski, Emsley)Microcrystalline proteins - An ideal benchmark for methodology development (Franks, van Rossum, Bardiaux, Ravera, Parigi, Luchinat, Oschkinat)Structural studies of protein fibrils by solid-state NMR (Böckmann, Meier)Membrane proteins (Cukkemane, Renault, Baldus)FRONTIERS IN

Ivano Bertini is the Founding Director of the Magnetic Resonance Center (CERM) at the University of Florence. He obtained the Italian degree of Doctor of Chemistry at the University of Florence in 1964, became an Assistant Professor in 1969, and Full Professor of General and Inorganic Chemistry in 1975. He is a member of the Academia Europaea and the Italian Accademia dei Lincei. He has authored over 600 scientific publications and is or has been on the editorial staff or advisory board of over 20 of the most authoritative journals in chemistry, biochemistry and inorganic chemistry.

Kathleen S. McGreevy is a researcher in bioinformatics at the Magnetic Resonance Center (CERM) at the University of Florence. Having obtained a degree in Mechanical Engineering from the University of Virginia in 2002, she also became involved in the support and management of research activities in the biomedical sciences before moving to her current position. She has been involved in the management of several European projects, notably the FP6-funded Coordination Action NMR-Life, from which this volume takes its inspiration.obtained the Italian degree of Doctor of Chemistry at the University of Florence in 1964, became an Assistant Professor in 1969, and Full Professor of General and Inorganic Chemistry in 1975. He is a member of the Academia Europaea and the Italian Accademia dei Lincei. He has authored over 600 scientific publications and is or has been on the editorial staff or advisory board of over 20 of the most authoritative journals in chemistry, biochemistry and inorganic chemistry.

Kathleen S. McGreevy is a researcher in bioinformatics at the Magnetic Resonance Center (CERM) at the University of Florence. Having obtained a degree in Mechanical Engineering from the University of Virginia in 2002, she also became involved in the support and management of research activities in the biomedical sciences before moving to her current position. She has been involved in the