Nutrigenomics: How Science Works

1Nutrition and common diseases1.1 Evolution of human nutrition1.2 Principles of metabolism 1.3 Dietary molecules1.4 Nutrition and metabolic diseases1.5 Nutrition and cancer1.6 Impact of physical activity2Human genomic variation2.1 Migration and evolutionary challenges of Homo sapiens2.2 Diversity of human populations2.3 Genetic variants of the human genome2.4 Haplotype blocks and GWAS2.5 The 1000 Genomes Project3Sensing nutrition3.1 Nutrient-sensing mechanisms3.2 Nuclear receptors as nutrient sensors3.3 Functions and actions of PPARs3.4 Integration of lipid metabolism by LXRs and FXR3.5 Coordination of the immune response by VDR3.6 Circadian control of metabolic processes4Interference of the human genome with nutrients4.1 Human genetic adaptions4.2 Genetic adaption to dietary changes4.3 Regulatory SNPs and quantitative traits4.4 Nutrigenomic analysis4.5 Personal omics profiles5Nutritional epigenetics5.1 Epigenetic mechanisms5.2 Intermediary metabolism and epigenetic signaling5.3 Nutrition-triggered transgenerational epigenetic inheritance5.4 Population epigenetics6Nutritional signaling and aging6.1 Aging and conserved nutrient-sensing pathways6.2 Neuroendocrine regulation of aging6.3 Principles of insulin signaling6.4 Central role of FOXO transcription factors6.5 Caloric restriction from yeast to mammals6.6 Cellular energy status sensing by sirtuins and AMPK7Chronic inflammation and metabolic stress7.1 Central role of monocytes and macrophages7.2 Acute and chronic inflammation7.3 Reverse cholesterol transport and inflammation7.4 Sensing metabolic stress via the ER8 Obesity8.1 Definition of obesity8.2 Adipogenesis8.3 Inflammation in adipose tissue8.4 Energy homeostasis and hormonal regulation of food uptake8.5 Genetics of obesity9 Insulin resistance and diabetes9.1 Glucose homeostasis9.2 Insulin resistance in skeletal muscle and liver
9.3 beta cell failure9.4 Definition of diabetes9.5 Disturbed glucose homeostasis in T2D and its treatment9.6 Genetics and

Prof. Carsten Carlberg: Professor for biochemistry at the School of Medicine, Institute of Biomedicine at the University of Eastern Finland. The main research interests of Prof. Carlberg are (epi)genomics of nuclear receptors and their ligands with special focus on vitamin D. So far he published more than 190 papers (H-index 50). Since 2003 he is lecturing yearly the course "Nutrigenomics", which is the basis of this textbook. Together with Dr. Molnár he also published the Springer textbook "Mechanisms of gene regulation".

Prof. Stine Marie Ulven: Professor at the Department of Nutrition, Institute of Basic Medical Sciences at the University of Oslo (Norway). The main research interests of Prof. Ulven are human dietary intervention studies and diet-gene interactions with particular focus on the role of dietary fat in prevention of chronic diseases. She has in total published 43 papers (H-index of 18).

Prof. Ferdinand Molnár: Associate Professor of Biology at the School of Sciences and Humanities, Department of Biology at the Nazarbayev University, Kazakhstan. The main research interests of Prof. Molnár are integrative structural biology and bioinformatics, eukaryotic transcriptional regulation in health and disease, and recombinant protein production. He has published 30 papers (H-index 19) on the molecular structure of nuclear receptor proteins and their natural and synthetic ligands. Together with Prof. Carlberg he published Springer textbooks on "Mechanisms of gene regulation", "Nutrigenomics" and "Epigenomics".