Organic Chemistry of Nucleic Acids

Reactions of Exocyclic Substituents of the Bases of Nucleic Acids and their Derivatives.- I. Introduction.- II. Substitution reactions at the nitrogen atom of an exocyclic amino group.- III. Substitutions at exocyclic oxygen and sulphur atoms.- 7 Reactions Involving the Cleavage or Regrouping of Heterocyclic Rings of the Bases of Nucleic acids and their Derivatives.- I. Introduction.- II. Reactions of cleavage and rearrangement of the rings by the action of nucleophilic agents.- III. Cleavage by the action of hydrazine.- IV. Cleavage by the action of hydroxylamine.- V. Cleavage of rings by the action of potassium permanganate and osmium tetroxide.- VI. Cleavage by the action of peroxide derivatives.- 8 Hydrolysis of N-Glycosidic Bonds in Nucleosides, Nucleotides and their Derivatives.- I. Introduction.- II. Hydrolysis of N-glycosidic bonds catalyzed by acids.- III. Hydrolysis of N-glycosidic bonds in pyrimidine deoxyribonucleosides, not catalyzed by acids or bases.- IV. Hydrolysis of N-glycosidic bonds in an alkaline medium.- V. Other reactions leading to cleavage of glycosidic bonds.- 9 Reactions of the Carbohydrate Residues of Nucleic Acids.- I. Introduction.- II. Acylation of hydroxyl groups of carbohydrate residues.- III. Alkylation of the hydroxyl groups of carbohydrate residues.- IV. Reactions of hydroxyl groups of carbohydrate residues with vinyl esters.- V. Reactions of hydroxyl groups of carbohydrate residues with carbonyl compounds and with their derivatives.- VI. Oxidation of carbohydrate residues.- 10 Cleavage of Phosphoester Bonds and some other Reactions of Phophate Groups of Nucleic Acids and their Derivatives.- I. Introduction.- II. Reactions with cleavage of P-O bonds.- III. Reactions with rupture of C-O bonds.- IV. Reactions leading to the formation of phosphoester bonds.- 11 Some Reactions of Minor Components of Nucleic Acids.- I. Introduction.- II. Reactions of 6-exo-N-isopentenyladenosine and its derivatives.- III. Reactions of pseudouridine and its derivatives.- IV. Reactions of 5-hydroxymethylpyrimidine derivatives.- 12 Photochemistry of the Nucleic Acids and their Components.- I Introduction.- II The basic concepts and laws of photochemistry.- III Absorption spectra of nucleic acids and their components.- IV Excited states of nucleic acids and their components.- V. Photochemical conversions of nucleic acids and their components.- VI. Photosensitized reactions.- VII. The photodynamic effect.- VIII. The action of visible light in the presence of iron ions.- IX. Photochemical reactions induced by excitation of a reagent.- X. Effect of chelating agents on photodimerization.- Index for Parts A and B.